Task Contribution of the Vestibular and Sympathetic Nervous Systems to Space-Induced Bone Loss (NSBRI Postdoctoral Fellowship) (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Nervous system & bone loss
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. To determine if VBX causes bone loss by activation of the sympathetic nervous system in the VBX model using b-blocker-treated mice and mice lacking the b2AR globally or specifically in osteoblasts.
  2. To analyze the bone phenotype of mice devoid of vestibular gravity sensor (Het-/- mice).
  3. To determine if vestibular stimulation by centrifugation could be used as a countermeasure to bone loss under microgravity.
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