Short Title:
Inflabrain
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
- Determine if inflammatory changes induced by a low dose of proton irradiation predisposes the hippocampus to abnormal neurogenesis after secondary TBI;
- Determine if inflammatory changes induced by a low dose of 56Fe irradiation predisposes the hippocampus to abnormal neurogenesis after secondary TBI;
- Using knock-out mice lacking chemokine receptor 2 (CCR2), determine if a muted monocytic inflammatory response can reverse the influence of low dose proton and/or 56Fe irradiation on TBI-induced alterations in neurogenesis; and
- Determine if pharmacologic intervention after proton and 56Fe irradiation will reduce radiation-induced inflammation and lessen the effects of subsequent TBI.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research providing evidence on the combined impact of HZE radiation and traumatic brain injury on inflammatory processes and neurogenesis, in support of CNS Gap 3 closure.
Internal Customers:
Space Radiation
External Customers:
None