Task Inflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Inflabrain
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Determine if inflammatory changes induced by a low dose of proton irradiation predisposes the hippocampus to abnormal neurogenesis after secondary TBI;
  2. Determine if inflammatory changes induced by a low dose of 56Fe irradiation predisposes the hippocampus to abnormal neurogenesis after secondary TBI;
  3. Using knock-out mice lacking chemokine receptor 2 (CCR2), determine if a muted monocytic inflammatory response can reverse the influence of low dose proton and/or 56Fe irradiation on TBI-induced alterations in neurogenesis; and
  4. Determine if pharmacologic intervention after proton and 56Fe irradiation will reduce radiation-induced inflammation and lessen the effects of subsequent TBI.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskInflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
You are here!TaskInflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult