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Task Mouse models approach for intestinal tumorigenesis estimates by space radiation (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Task Book: Entry
Principal Investigator: Fornace, Albert
Short Title: Mouse Models SR
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Quantitatively compare HZE ion or high-energy proton irradiation to gamma-ray effects on intestinal tumor incidence and grade using the Apc+/min tumor model.
  2. Characterize and compare inactivation of wt APC locus on chromosome 18B1 after gamma vs. HZE ion or high-energy proton irradiation with the Apc+/min tumor model.
  3. Determine intestinal tumor incidence in the Apc+/min; Ppm1d-/- mouse model and mechanisms for reactivation of the Apc+/min tumor phenotype by radiation.
  4. Determine molecular signatures by comparative genomic hybridization (CGH) and expression profiling in spontaneous intestinal tumors compared to those induced by HZE ions, high-energy protons, and gamma irradiation.
  5. Quantitatively compare HZE ion or high-energy proton irradiation vs. gamma-ray effects on incidence of other tumors.
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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskMouse models approach for intestinal tumorigenesis estimates by space radiation
RiskRisk of Cardiovascular Disease and Other Degenerative Tissue Effects From Radiation Exposure and Secondary Spaceflight Stressors
You are here!TaskMouse models approach for intestinal tumorigenesis estimates by space radiation
RiskRisk of Radiation Carcinogenesis
You are here!TaskMouse models approach for intestinal tumorigenesis estimates by space radiation