Task A role for homologous recombination in complex DSB repair after HZE particles (Completed)
Last Published:  03/29/18 08:54:56 AM (Central)
Short Title: HZE Homologous Recombination
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. To test the contribution of homologous recombinational repair (HR) in repairing DNA damaged sites induced by high-energy Fe ions, using HR-deficient rodent cells carrying a deletion in the RAD51D gene
  2. To test the contribution of homologous recombinational repair (HR) in repairing DNA damaged sites induced by high-energy Fe ions using syngeneic human cells impaired for HR by RAD51D or RAD51 knockdown using RNA interference.
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