Task Increasing the Efficiency of Exercise Countermeasures for Bone Loss (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Bone Exercise CM
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Test two different modes of resistance training (electrically stimulated muscle contractions versus voluntary resistance exercise) for their effects on mitigating bone and muscle decrements during 28 days of hindlimb unloading (HU) in adult rats.
  2. Test different doses of alendronate during 28 days HU for maximal efficacy in suppressing bone resorption.
  3. Combine alendronate with that training paradigm judged most successful to test for additive or synergistic effects.
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