HRR - Task - Redox Modulation of Skeletal Muscle Function in Microgravity

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Redox Modulation of Skeletal Muscle Function in Microgravity (Completed)

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry
Principal Investigator: Reid, Michael

Short Title: Redox Modulation

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

To determine the time course, composition, and source of increased oxidant activity in unloaded muscle.
To evaluate selected antioxidants as countermeasures for weakness in unloaded muscle.
To test NAC as a countermeasure for handgrip fatigue in humans.

Resources (None Listed)

Deliverables (0)

Mappings

Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

Redox Modulation of Skeletal Muscle Function in Microgravity

Related Tasks (65)

Standardized “Pre-flight” Exercise Tests to Predict Performance during Extravehicular Activities in a Lunar Environment

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Testosterone Supplementation as a Countermeasure against Musculoskeletal Losses during Space Exploration

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Biomechanical Analysis of Treadmill Locomotion on the International Space Station

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Integrated Endurance and Resistance Exercise Countermeasures Using a Gravity Independent Training Device

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Ground-based Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

A New Harness For Use with Exercise Countermeasures-Validation of Improved Comfort and Loading with the Center for Space Medicine (CSM) Harness

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Reliability of the Power Cycle: A Comparsion to Current NASA Exercise Laboratory Muscle Performance Tests

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Enhancing the Efficacy of Musculoskeletal Countermeasures Using Computer Simulation

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Assessment of the Time Courses of Leg Muscle Strength and Performance Losses During Prolonged Spaceflight using MARES (Laughlin)

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Space Suit Simulator (S3) for Partial Gravity EVA Experimentation and Testing

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

ESPRIT: Exercise Sensing and Pose Recovery Inference Tool

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

The Constant Force Resistive Exercise Unit (CFREU) for Multi-Functional Exercise

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Modulation of Muscle Function by Lower Limb Loading during Space Flight

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Development of a Submaximal Cycling Protocol to Identify the Ventilatory Threshold in Astronauts: Application to Monitor Changes in Endurance Capacity in Response to Long-Duration Spaceflight Missions

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Compact, Controlled Force Crew Exercise System

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Controlled Resistance Exercise Device

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Computer-Controlled Force Generator

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

ON HOLD: Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device (Ferrigno)

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

In-flight Demonstration of Portable Load Monitoring Devices-Phase I: XSENS ForceShoe™

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Retrospective analysis of inflight exercise loading and health outcomes

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Identification of skeletal muscle performance thresholds for extended duration functional task performance.

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Evaluation of Advanced Exercise Concepts Devices for Down-Select Decision (Perusek)

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Exploring the Relationship between In-Flight Training Load Data and Musculoskeletal Health Outcomes

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

EVA Health and Human Performance Benchmarking Study

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Identification of Muscle Fitness Standards For Exploration Mission Tasks

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Gravitational dose and multi-system physiologic response

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Development of a Muscle Adaptation in Space-flight Simulator ("MASS")

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Temporal changes in astronauts muscle and cardiorespiratory physiology pre, during, and post spaceflight (Downs)

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance
	M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

Time Course of Spaceflight-Induced Adaptations in Bone Morphology, Bone Strength and Muscle Quality (Bouxsein)

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

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PRRs (1)

This task can be found in the following Paths to Risk Reduction.

Muscle Path to Risk Reduction

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