HRR - Task - Redox Modulation of Skeletal Muscle Function in Microgravity

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Redox Modulation of Skeletal Muscle Function in Microgravity (Completed)

Last Published: 07/29/22 01:33:24 PM (Central)

Task Book: Entry
Principal Investigator: Reid, Michael

Short Title: Redox Modulation

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

To determine the time course, composition, and source of increased oxidant activity in unloaded muscle.
To evaluate selected antioxidants as countermeasures for weakness in unloaded muscle.
To test NAC as a countermeasure for handgrip fatigue in humans.

Resources (None Listed)

Deliverables (0)

Mappings

Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

Redox Modulation of Skeletal Muscle Function in Microgravity

Related Tasks (67)

Standardized “Pre-flight” Exercise Tests to Predict Performance during Extravehicular Activities in a Lunar Environment

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Integrated Resistance and Aerobic Training Study (Ploutz-Snyder)

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Testosterone Supplementation as a Countermeasure against Musculoskeletal Losses during Space Exploration

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Biomechanical Analysis of Treadmill Locomotion on the International Space Station

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Integrated Endurance and Resistance Exercise Countermeasures Using a Gravity Independent Training Device

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Ground-based Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

A New Harness For Use with Exercise Countermeasures-Validation of Improved Comfort and Loading with the Center for Space Medicine (CSM) Harness

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance
	M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Reliability of the Power Cycle: A Comparsion to Current NASA Exercise Laboratory Muscle Performance Tests

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Enhancing the Efficacy of Musculoskeletal Countermeasures Using Computer Simulation

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Assessment of the Time Courses of Leg Muscle Strength and Performance Losses During Prolonged Spaceflight using MARES (Laughlin)

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Space Suit Simulator (S3) for Partial Gravity EVA Experimentation and Testing

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

ESPRIT: Exercise Sensing and Pose Recovery Inference Tool

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

The Constant Force Resistive Exercise Unit (CFREU) for Multi-Functional Exercise

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Integrated Resistance and Aerobic Exercise Training with Small Compact Exercise Equipment

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Modulation of Muscle Function by Lower Limb Loading during Space Flight

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Development of a Submaximal Cycling Protocol to Identify the Ventilatory Threshold in Astronauts: Application to Monitor Changes in Endurance Capacity in Response to Long-Duration Spaceflight Missions

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Compact, Controlled Force Crew Exercise System

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Controlled Resistance Exercise Device

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Computer-Controlled Force Generator

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Biomechanical Analyses of Resistance Exercise Using the Advanced Resistive Exercise Device (Ferrigno)

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

In-flight Demonstration of Portable Load Monitoring Devices-Phase I: XSENS ForceShoe™

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Retrospective analysis of inflight exercise loading and health outcomes

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Identification of skeletal muscle performance thresholds for extended duration functional task performance.

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance
	M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance
	M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Evaluation of Advanced Exercise Concepts Devices for Down-Select Decision (Perusek)

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Exploring the Relationship between In-Flight Training Load Data and Musculoskeletal Health Outcomes

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

EVA Health and Human Performance Benchmarking Study

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Identification of Muscle Fitness Standards For Exploration Mission Tasks

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Identification of Functional Metabolomic Profiles Contributing to Physiological Adaptations to Simulated Spaceflight. (Rana)

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Gravitational dose and multi-system physiologic response

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Musculoskeletal response to a partial-gravity analog in rats: structural, functional and molecular alterations (Rutkove)

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Development of a Muscle Adaptation in Space-flight Simulator ("MASS")

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Temporal changes in astronauts muscle and cardiorespiratory physiology pre, during, and post spaceflight (Rivas)

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance
	M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

Dose-Response Study of Musculoskeletal Outcomes Following Centrifugation in Adult Mice on ISS (Bouxsein)

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Time Course of Spaceflight-Induced Adaptations in Bone Morphology, Bone Strength and Muscle Quality (Bouxsein)

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	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Physical and Cognitive Subject Characterization in Support of Aerobic Fitness and Muscle Strength Fitness for Duty Standards (Rivas)

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

Alterations in Energy Metabolism Pathways in Skeletal Muscle in Relation to Microgravity Analog and Space Radiation

Common Item(s)
	Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance
	M23: Determine if factors other than unloading contribute to muscle atrophy during space flight.

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Risk Approach Plans (1)

This task can be found in the following Risk Approach Plans.

Muscle Risk Approach plan

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