Short Title:
Hippocampal
Responsible HRP Element:
Space Radiation
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Collaborating Org(s):
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| Department of Energy (DoE) |
| Other: |
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Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
We have profiled gene expression patterns in the dentate gyrus and find significant effects at even the lowest doses tested (3 cGy). Further analysis of our extensive microarray data is underway to better understand the microenvironmental changes elicited by radiation that influence neuronal cell genesis and survival.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research will provide evidence, through global gene expression profiling, on low-dose radiation effects on the microenvironment in the adult mammalian brain, which may impact neurogenesis in the dentate gyrus. Evidence will support closure of CNS Gap 1.
Internal Customers:
None
External Customers:
None