HRR - Task - Low Dose Radiation Cataract

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Low Dose Radiation Cataract (Completed)

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Kleiman, Norman

Short Title: Low dose cataract

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Department of Energy (DoE)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:

Our research utilizes radiation cataract as a model system to study the effects of low-dose ionizing radiation exposure in a complex, highly differentiated tissue. We believe radiation cataract is a useful model to determine the genetic and individual basis for risk from ionizing radiation with particular relevance to carcinogenesis and radiation induced DNA damage, repair and cell cycle control.

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Final Report

Internal Customers:
None External Customers:
None

Mappings

Risk of Spaceflight Induced Cardiovascular Disease

CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Low Dose Radiation Cataract

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	Risk of Spaceflight Induced Cardiovascular Disease
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	Risk of Spaceflight Induced Cardiovascular Disease
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	Risk of Spaceflight Induced Cardiovascular Disease
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	Risk of Spaceflight Induced Cardiovascular Disease
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	Risk of Spaceflight Induced Cardiovascular Disease

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	Risk of Spaceflight Induced Cardiovascular Disease

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	Risk of Spaceflight Induced Cardiovascular Disease

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	Risk of Spaceflight Induced Cardiovascular Disease

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	Risk of Spaceflight Induced Cardiovascular Disease

Center for Medical Countermeasures II – Cross Risk

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

2022 NSCOR-CVD/Late CNS: Impact of Combined Spaceflight Stressors

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
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Mars 600/900 Simulation II: Large Animal Chronic Studies

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	Risk of Spaceflight Induced Cardiovascular Disease
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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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	Risk of Spaceflight Induced Cardiovascular Disease
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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Multi-Model Ensemble Risk Assessment

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Space Relevant Radiation-Induced Cardiovascular Disease Risk Thresholds: Effect of Gender on the Outcome

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

The Effect of Simulated Space Radiation on the Interaction of the Metabolome, Immune System and Lymphatic Anatomy of the Gastrointestinal Tract

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Cardiovascular responses to simulated spaceflight: molecular signatures and surrogate outputs to measure CVD risk.

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

Determining the Dose Response Profile of the Headward Fluid Shift during Varying Gravity Levels (Lee)

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease

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