Task Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Stem Cell Plasticity
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. One aspect this proposal will focus on is how radiation leads to the types of changes in the brain that might lead to impaired cognition. Much of our past work has demonstrated that the sensitive populations of neural stem and precursors cells that are important to cognitive health exhibit long-lasting chemical changes caused by prior radiation exposure. These changes have been linked to many of the adverse effects found in the brain after irradiation, and our present study will continue to identify the pathways that are activated by irradiation that cause these long-term and adverse chemical changes.
  2. Another aspect of our proposal relates to the rate at which cells are exposed to the radiation. A given dose of total radiation can be given over short or long time frames; if that exposure time is short then the rate is higher that if that dose is delivered over longer periods of time. Much of our past data of space radiation effects in the brain have been done under conditions of high dose rate, largely due to a number of practical limitations. In space however, most dose rates are low, and because the response of cells might differ, studies are needed to determine how cells respond to the types of radiation in space when delivered at low dose rates. Our current proposal will compare the types of changes found in neural precursor cells at low dose rate to those changes found previously at high dose rate. Results from these studies will be critical in enhancing our knowledge base of the risks associated with exposure of the brain to the radiation fields in space.
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