Task A Scanning Confocal Acoustic Diagnostic System for Non-Invasively Assessing Bone Quality (Completed)
Last Published:  07/31/18 09:30:09 AM (Central)
Short Title: Acoustic Bone Quality
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
NSBRI
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

1: Developed a rapid scanning confocal acoustic diagnostic (SCAD) system capable of generating high-resolution acoustic images for trabecular structural and strength properties in the region of interest (ROI).

2: Developed the system capable of extracting trabecular broadband ultrasound attenuation (BUA) and UV images at multiple skeletal sites, i.e., calcaneus, wrist, and knee, providing evaluation of loss and fracture risk.

3: Evaluated the capability of the SCAD system in testing bone's structure and strength in cadavers by micro-CT determined microstructure, nanoindentor tested integrity, and modulus.

4: Correlated the degree of osteoporosis and disuse osteopenia in human to determine the relationship to age, gender, degree of bone loss and rational effects at ROI using SCAD and DXA.

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