Short Title:
Cardio Adaption
Responsible HRP Element:
Human Health Countermeasures
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Collaborating Org(s):
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| National Space Biomedical Research Institute (NSBRI) |
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Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
- Extension of work to calculate two-dimensional
myocardial strain, improving sensitivity for detecting preclinical
alterations in cardiac function.
- To apply 2D strain in graded exercise to detect
myocardial dysfunction in its earliest phases, allowing both diagnostic
capabilities and a means of judging exercise as a countermeasure.
- To continue our ongoing study of the magnitude and
predictors of LV mass regression following acute volume and pressure
unloading as a ground-based analog for manned spaceflight.
- To develop, in collaboration with OBPR Fundamental
Physics scientists from Glenn, a sophisticated fluid-structure model of
the left ventricle constrained by the pericardium to investigate the
impact that microgravity has on unloading the heart by a removal of
pericardial constraint.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
See TaskBook entry.
Internal Customers:
Human Health Countermeasures
External Customers:
None