Short Title:
HZE Neural
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
- Determine the impact of 56Fe and gamma-ray irradiation on proliferation and differentiation of K048 cells in vitro.
- Determine gene expression patterns and apoptotic responses of proliferating and differentiating K048 cells following 56Fe and gamma-ray irradiation.
- Determine whether in vitro primed K048 cells can differentiate into neurons when grafted into neurogenic and non-neurogenic regions of rat brains damaged by 56Fe and gamma-rays.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research to provide evidence on mechanisms of radiation effects on differentiation and proliferation of neural stem cells, in support of CNS Gap 1 closure.
Internal Customers:
Space Radiation
External Customers:
None