Short Title:
Metabolomics
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
- We will perform an integrated NMR and LC-MS metabolomics study of the impact of exposing mice and rats to 0, 0.5, and 3 Gy using both high LET proton and iron ion radiation. The metabolic perturbations in global physiology and the subsequent health outcomes will be investigated from 1 day to 1 year post irradiation using key body fluids and excised tissues.
- In parallel, we will investigate the impact of exposing mice and rats to gamma-rays at low and high doses to determine the differences in dose-dependent effects between proton, iron ions and gamma-rays.
- Furthermore, histopathologic analysis and basic-translational cell and molecular investigations will be used to link metabolic "signatures" and disease pathogenesis.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final Report
Internal Customers:
None
External Customers:
None