HRR - Task - Pre & Postflight MRV review (central venous congestion) [VIIP MRV/RIASCOS/COMPLETED]

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Pre & Postflight MRV review (central venous congestion) [VIIP MRV/RIASCOS/COMPLETED] (Completed)

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Riascos-Castaneda, Roy

Short Title: VIIP MRV

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Space Medicine Medical Operations (SMMO)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Aims:
NASA JSC’s Space Medicine group has added magnetic resonance venography (MRV) to the clinical monitoring protocol to evaluate central venous congestion and stenosis in astronauts pre and postflight. The MRVs will be collected as part of the standard medical requirements testing performed on all crew members using medical operations resources.

Resources (Flight)

Flight Resources

Number of Subjects

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
rVIIP can request access to the results to determine the degree of central venous congestion and or stenosis of the crew members and its potential influence on the VIIP syndrome.

Internal Customers:
None External Customers:
None

Mappings

Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Pre & Postflight MRV review (central venous congestion) [VIIP MRV/RIASCOS/COMPLETED]

Related Tasks (93)

Hindlimb suspension (HS) as an analog model of ocular alterations associated with cephalad fluid shifts: resveratrol as a countermeasure

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Spaceflight effects on the mouse retina: Histological, gene expression and epigenetic changes after flight on STS-135

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Pilot study to evaluate a novel non-invasive technology to estimate peripheral and central venous pressure

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

rVisual Impairment and Intracranial Pressure Project Data Mining

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Combined effects of gamma radiation and high dietary iron on oxidative damage and antioxidant status in rat eyes

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD-OCT Analysis of The Optic Nerve Head and Surrounding Structures in Long Duration ISS Crew Members Compared to Terrestrial Bound Normals [SD-OCT ANALYSIS/PASS/COMPLETED

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Prospective Observational Study of Ocular Health in ISS Crews (Macias)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

A data mining project to identify cardiovascular related factors that may contribute to changes in visual acuity within the astronaut corps

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Risk of visual impairment and intracranial hypertension after space flight: Evaluation of the role of polymorphism of enzymes involved in one-carbon metabolism [ONE-CARBON METABOLISM/SMITH]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Are Medications Involved in Vision and Intracranial Pressure Changes Seen in Spaceflight? [VIIP PHARM/WOTRING]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Development of in-flight fundoscopy

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Fundoscopy Trade Study

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Development of in-flight diagnostic OCT

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Diagnostic OCT Trade Study

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

ICP Tech Search (Innocentive, Yet To Come) COMPLETED

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of Microgravity on Intracranial Pressure [MICROGRAVITY ICP/LEVINE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Analysis of a Clinical Database as a Means to Validate Non-invasive Assessment of Intracranial Pressure Using the Cerebral and Cochlear Fluid Pressure (CCFP) Analyzer [CCFP DATA MINING/EBERT/COMPLETED]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SD/Upgrade Visual Acuity Software and In-flight Tonometer

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Non-invasive ICP device purchase & evaluation [VITTAMED ICP DEVICE EVALUATION/BERSHAD]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Head-down tilt as a model for intracranial and intraocular pressures, and retinal changes during spaceflight (Fuller)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Integrative physiology of VIIP: cardiopulmonary, sleep, and cognitive function assessment during hypercapnic bed rest [Thirty-day CO2 Bedrest/LAURIE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Retrospective Pre and postflight measurement of cerebrospinal fluid (CSF) dynamics [MR-ICP CSF DYNAMICS RETROSPECTIVE/ALPERIN]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Brain Gene Expression Signatures from Cerebrospinal Fluid Exosome RNA Profiling [CSF EXOSOME GROUND/ZANELLO]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Risk of Spaceflight-Induced Intracranial Hypertension/Vision Alterations Evidence Report

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Microgravity Associated Compartmental Equilibration (Dulchavsky)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Fluid Distribution before, during and after Prolonged Space Flight (Hargens)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Human Cerebral Vascular Autoregulation and Venous Outflow in Response to Microgravity-Induced Cephalad Fluid Redistribution (Roberts)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Distribution of Body Fluids during Long Duration Space Flight and Subsequent Effects on Intraocular Pressure and Vision Disturbance (Stenger)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Evaluation of Hindlimb Suspension as a Model to Study Ophthalmic Complications in Microgravity: Ocular Structure and Function and Association with Intracranial Pressure (Zanello)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Non-Invasive Monitoring of Intracranial Pressure (ICP) with Volumetric Ophthalmic Ultrasound [ULTRASOUND ICP/DENTINGER]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Comparison of Continuous Non-Invasive and Invasive Intracranial Pressure Measurement [NON-INVASIVE ICP GROUND COMPARISON/WILLIAMS/COMPLETED]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Association of Diffusion Tensor Imaging Parameters of Optic Tracts and Cerebral White Matter Tracts with Visual Impairment and Structural Changes of the Eyes and Optic Nerves in Long-Duration Microgravity Exposure [DTI/RIASCOS]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

A gene expression and histological approach to the study of cerebrospinal fluid production and outflow in rats (Zanello)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

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Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

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Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

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Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

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Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

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Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

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Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

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Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Digital Astronaut: VIIP Modeling

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Assess Glymphatic Changes for Spaceflight

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

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Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of short term hypercapnia during head-down tilt on ocular structures, cerebral blood flow, and visual acuity in healthy human subjects [CO2 TILT/LAURIE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SPACECOT: Studying Physiological and Anatomical Cerebral Effects of CO2 and Tilt [SPACECOT/BERSHAD]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Evaluation of an Impedance Threshold Device as a Vision Impairment and Intracranial Pressure (VIIP) Countermeasure [IMPEDANCE THRESHOLD COUNTERMEASURE/EBERT]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Validation of a Cephalad Fluid Shift Countermeasures [FLUID SHIFT COUNTERMEASURE/MACIAS]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Multimodal Modeling towards Noninvasive Assessment of Intracranial Pressure in Weightlessness and Biomarker Identification of Predisposition to VIIP Syndrome (Zanello)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

VIIP and One-Carbon Metabolism: Expanded Polymorphism Evaluation and Polycystic Ovary Syndrome Pilot Study (Smith)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

STOP VIIP Study: Safe and Effective Countermeasures to Reduce Intracranial Pressure and Ameliorate VIIP in Astronauts [STOP VIIP/Levine]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Comparing Globe Distortions Following Head-Down Bed Rest to those Measured in Astronauts in Short and Long-Duration Spaceflights [Thirty-day CO2 Bedrest/ALPERIN/ACTIVE]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Clinical Evaluation of the Newest Generation of a Non-Invasive ICP Meter (Vittamed) in Subjects Undergoing Invasive ICP Measurement [VITTAMED 2/BERSHAD]

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Optical System for Monitoring Net Ocular Blood Flow (Mujat)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Identification of functional metabolomic alterations during the simulated spaceflight environment. (Rana)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Gravitational dose and multi-system physiologic response

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Impact of +Gz and -Gz induced fluid shifts on ocular and cerebral parameters during simulated Orion re-entry.

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

VIIP Simulations of CSF, Hemodynamics and Ocular Risk (Ethier)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

SANS Integrated Flight Countermeasure Studies

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Eye Vein Pressure Device (Sit)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Mechanical and gravitational countermeasures to ocular changes during strict head-down tilt bedrest (Marshall-Goebel)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Exploration Atmosphere Bedrest

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Self-Generated LBNP for Deep-Space Missions (Hargens)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of microgravity on ocular vascular hydrodynamics - ISS (Zawieja)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Investigating Structure and Function of the Eye - ISS (Macias)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

SPACE-CENT: Studying the Physiological and Anatomical Cerebral Effects of CENTrifugation and Head Down Tilt Bed Rest (Bershad)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS Data Integration using IMPALA

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Effects of low-dose radiation on neurovascular remodeling and blood-retina barrier function in mice, rats and rabbits (Mao)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Markers of Vascular Risks Associated with Spaceflight Associated Neuro-ocular Syndrome - ISS (Hein)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Changes of the optic nerve dura mater in astronauts and SANS (Ethier)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Characterizing the Baselines of Sleep Quality, Cognitive / Operational Performance, Immune Function, and Intracranial Fluids for Deep Space Expeditions

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Long-term Ocular & Brain Changes - ISS (Macias)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Mobile Gravity Suit, An Integrative Countermeasure Device (Petersen)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Predicting acute cardiovascular and ocular changes due to changes in the gravitational vector and effects of countermeasures - Lab (Diaz Artiles)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

A Non-intrusive Ocular Monitoring Framework to Model Ocular Structure and Functional Changes due to Long-term Spaceflight (Tavakkoli)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Telemetric Monitoring of Intracranial Pressure in Astronauts Before, During, and After Spaceflight - ISS

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Exercise Countermeasure to Prevent Ocular Structural and Functional Changes in a Terrestrial Model of SANS - Bedrest (Huang)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

B Complex: 5-Methyltetrahydrofolate, Riboflavin, Pyridoxine, and Methylcobalamin Supplementation as a Non-Mechanical Countermeasure to Mitigate Optic Disc Edema Changes During Strict 6º Head-Down Tilt Bed Rest (Zwart)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Lower Body Negative Pressure Device Flight Demo - ISS

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Mitigating headward fluid shifts and vision impairment with thigh cuffs during spaceflight - ISS

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Rat Radiation + ISS Flight

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Gateway SANS Occupational & Research Monitoring

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Measuring Transcutaneous Partial Pressure of Carbon Dioxide (PCO2) to Estimate Arterial PCO2 during Spaceflight

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS Larger Animal HLS + Radiation Study - Lab

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Recovery Timeline of Spaceflight-Induced Central Nervous System Changes

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

Gateway SANS Research Mini-OCT

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

Long-Term Brain Structural and Functional Consequences of Spaceflight

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
	SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

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SANS Risk Approach plan

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