HRR - Task - Inner Ear Otoconia Response in Mice to Micro- and Hyper-gravity (Boyle)

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Inner Ear Otoconia Response in Mice to Micro- and Hyper-gravity (Boyle) (Completed)

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry
Principal Investigator: Boyle, Richard

Short Title: Otoconia

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:
Apply scanning and transmission electron microscopy and microstructural-crystallographic techniques to evaluate the possible mechanisms of otoconia restructuring in response to gravity loading and answer the following questions:

1) Are there structural changes in otoconia as a result of experimental altered gravity conditions?
2) If so, is the change due to a constructive or destructive process?
3) And, is the process dependent on length of exposure to altered gravity loading?

Resources (Other)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
This task contributed to gap closure by providing evidence that there are inner ear otoconia structural changes due to long-duration altered gravity exposures. (hyper- and hypo-gravity).

Internal Customers:
Human Health Countermeasures
External Customers:
None

Mappings

Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

SM-101: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after G transitions.

SM-102: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on manual control (fine motor control) after G transitions.

SM-103: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on spatial orientation and motion sickness after G transitions.

Inner Ear Otoconia Response in Mice to Micro- and Hyper-gravity (Boyle)

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Risk Approach Plans (2)

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Common Item(s)
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	SM-101: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after G transitions.
	SM-103: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on spatial orientation and motion sickness after G transitions.