Task Bed Rest as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases (Seidler) (Completed)
Last Published:  04/20/22 11:43:24 AM (Central)
Short Title: Neuromapping - Bedrest
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Behavioral Health & Performance (BHP) Element
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):


Aim 1- Identify changes in brain structure, function, and network integrity as a function of 60 days head down tilt bed rest and characterize their time course:  We will acquire brain structural and functional images at two time points pre, two time points during, and three time points post bed rest in 15 individuals and 15 age- and gender-matched controls.  We hypothesize that bed rest participants will exhibit changes from pre to post the intervention that are significantly greater than those seen in control participants across the same time period.  Scans conducted during and following bed rest will characterize the time course of changes and recovery. 

Aim 2- Specify relationships between structural and functional brain changes and performance and characterize their time course:  We will administer a broad ranging battery of sensory, motor, and cognitive assessments at the time points described for Aim 1.  We hypothesize that bed rest participants will exhibit pre- to post-intervention decrements in sensorimotor performance as we have shown in our past work, which will correlate with the neural changes identified under Aim 1.  Additionally, for some measures and time points, we expect that there will be no performance effects despite alterations in brain structure and function due to compensatory brain processes that will be identifiable with neuroimaging approaches.

This is the same protocol as that being performed with astronauts in the NeuroMapping flight study.

This task also informs VIIP1 gap and the HCI and BMed Risks.