Task Astronaut Bone Medical Standards Derived from Finite Element [FE] Modeling of QCT Scans from Populations Studies (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: FE Strength Cutoff II
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:
1) Develop a dataset of FE hip strengths from human subjects: with ages covering the age
range of the astronauts and for which fracture outcome data have been collected.
a. The Rochester Bone Health Study will provide QCT scans from 408 persons to
Dr. Joyce Keyak who will estimate hip bone strength using her developed FEM at
UCI (Keyak, 2005).
b. FE data from 1a (above) will be combined with FE data generated from other
applications of Keyak FEM to QCT scans of study cohorts, which includes ISS
astronauts.

2) Determine FE strength cutoffs from to be used as a decision-tool by Space Medicine for
the following scheduled decision points (a-d):
a. to qualify an applicant for astronaut candidacy
b. to qualify an astronaut for a long-duration (LD) mission
c. to qualify a veteran LD astronaut for a second LD mission
d. to establish responsibility by occupational space medicine for a post-mission
fracture or osteoporosis diagnosis.

3) Review and finalize generated FE strength cutoffs with FE Task Group (along with the
inclusion of cohort biostatisticians) to recommend to Human Health Countermeasures as
a deliverable to Space Medicine and Office of Chief Health and Medical Officer.

Integration/Unique Aspects: This task convened a "Bone Summit" -- an expert panel comprised of policy-makers in the International Society of Clinical Densitometry (ISCD), World Health Organization (WHO) and practitioners in the field of osteoporosis -- to review NASA’s assessment of skeletal integrity in astronauts and make recommendations on how best to assess skeletal integrity in astronauts.
Mappings