HRR - Task - High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo

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High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB (Completed)

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry
Principal Investigator: Naidu, Mamta

Short Title: OPC II

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Determine the effects of high LET radiation on the nuclear and mitochondrial BER in two systems:

the central glia-4 (CG-4), a glial progenitor cell line that can differentiate into OL or astrocytes, and
In OPC cells isolated from rat spinal cord.

Resources (Other)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Research will determine the effects of high LET radiation on the nuclear and mitochondrial DNA repair pathways in cells of the CNS. This data will provide evidence for risk characterization in support of CNS Gap 2 closure.

Internal Customers:
None External Customers:
None

Mappings

Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure

CNS - 7: What are the best shielding approaches to protect against CNS risks, and are shielding approaches for CNS and cancer risks synergistic?

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB

Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB

Related Tasks (421)

Common Item(s)
	Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure