Task Charged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Plasticity and Neurodegeneration
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
To address the foregoing problems we will measure the impact of charged particle irradiation on neuronal anatomy and function using cultures of human neurons grown in the presence and absence of additional cell types known to be critical for proper neuronal function. Studies will also be performed in the presence of antioxidants that can minimize damage from reactive species, providing a useful strategy for gauging the importance of radiation-induced oxidative stress. These cell-based studies will be complemented by animal studies in which similar endpoints will be measured in brain tissue isolated from irradiated mice. One animal model genetically modified to express a neuronal fluorescent marker will be used to measure the subtle structural changes to neurons after irradiation. Another animal model genetically modified to exhibit early onset dementia will be used to gauge how exposure to charged particles found in space might impact the onset and/or severity of neurodegenerative phenotypes.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCNS - 6: How can new knowledge and data from molecular, cellular, tissue and animal models of late CNS risks or clinical human data be used to estimate late CNS risks to astronauts from GCR and SPE?
You are here!TaskCharged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
You are here!TaskCharged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration