Short Title:
HZE Individual CNS
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
|
|
Aims:
- Evaluate the effects of repeated subthreshold exposures to HZE particles and protons on cognitive and neuronal deficits and how they relate to the characteristics of the specific particle.
- Determine the relationship between changes in performance and HZE particle- and proton-induced changes in oxidative stress, inflammation, signaling molecules and autophagy in key brain regions.
- Determine how individual characteristics, including age and sex, may influence the responsiveness of the individual to HZE particle irradiation.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Research will characterize the impact of gender and age on modulation of the effects of space radiation exposure on neurocognitive endpoints important in early CNS effects. Research will provide risk characterization in support of CNS Gap 3 closure.
Internal Customers:
None
External Customers:
None