Task Effects of Space Radiation on Long Term Synaptic Plasticity and Neurogenesis in Normal and Alzheimer's Disease Transgenic Mice (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: SR Synaptic Plasticity
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:
  1. Examine the long-term impact of Space Radiation on electrical communication between neurons, and changes in function and fine structure of the sites known as 'dendritic spines' where neurons form synaptic contacts to communicate with one another.
  2. Determine whether Space Radiation, in reducing neurogenesis, also alters the functionality of newly-born neurons.
  3. Determine whether, in the most widely-studied animal model of human Alzheimer's disease, Space Radiation differentially affects electrical or physical function of neurons, and/or accelerates the disease process.

 

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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskEffects of Space Radiation on Long Term Synaptic Plasticity and Neurogenesis in Normal and Alzheimer's Disease Transgenic Mice

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
You are here!TaskEffects of Space Radiation on Long Term Synaptic Plasticity and Neurogenesis in Normal and Alzheimer's Disease Transgenic Mice