HRR - Task - Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)

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Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry
Principal Investigator: Williams, Michael

Short Title: Direct ICP

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Space Medicine Medical Operations (SMMO)

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Original Aims
Specific Aim 1: Determine whether ICP in space is elevated in comparison to baseline ICP on Earth, and whether ICP after return to Earth differs from baseline values by measuring ICP in astronauts before, during, and after an ISS mission by invasive methods.

Specific Aim 2: Validate noninvasive ICP measurement methods and their correlation with invasive ICP before, during, and after spaceflight, and to quantify their error of measurement.

Specific Aim 3: Determine the correlation of ICP changes to other indicators of SANS by collecting biomarkers of SANS for correlation to ICP.

This study was merged with Zanello's "Multimodal Modeling towards Noninvasive Assessment of Intracranial Pressure in Weightlessness and Biomarker Identification of Predisposition to VIIP Syndrome." https://humanresearchroadmap.nasa.gov/Tasks/task.aspx?i=2058 . This work will now be completed by Dr. Williams. The aims from the formerly Zanello study are below.

Additional Aims
Specific Aim 1 (Hypothesis #1 and #2)

- To develop and validate a noninvasive ICP estimation (nICP) approach for a specific

population of crewmembers based on a noninvasive ICP framework (NICF). The anticipated

input parameters may include: arterial blood pressure (ABP), electrocardiogram signals, cerebral

blood flow velocity (CBFV), heart and ventilation rate, tympanic membrane displacement by

Cochlear and Cerebrospinal Fluid Pressure (CCFP), ophthalmic artery blood pressure by

Vittamed. The NICF has been only tested using ABP and CBFV data from brain injury patients.

The additional noninvasive data elements provide different aspects of cerebral physiology under

influence of ICP. Therefore, integrating them under the NICF is very likely to improve nICP

accuracy.

Specific Aim 2 (Hypothesis #2)

- To longitudinally estimate ICP in crew members before, during and after spaceflight using the

model developed in Aim 1.

Specific Aim 3 (Hypothesis #3)

- To use novel methods of mRNA and microRNA profiling to identify candidate urinary and

plasma biomarkers that align with SANS-related physiologic variables.

Specific Aim 4 (Hypothesis #4)

-To measure and correlate novel biomarkers in urine and blood of crew members with measures

of estimated ICP, pre-, in- and post-flight.

-To use all noninvasive measures plus biomarkers as input to build a predictive model that will

inform the likelihood of a given crew member developing SANS post flight.

Resources (Flight)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
The deliverable will be a report summarizing a combination of: the dynamics of intracranial pressure during spaceflight, its response to various countermeasures (if applicable), and unique biomarkers in long-duration crewmembers. This report will contribute to VIIP 1 knowledge gap closure by reporting pre-, in-, and postflight intracranial pressure values for long duration crew members. The report might contribute to the VIIP 13 knowledge gap by providing an evaluation of countermeasure efficacies because data will be collected from crewmembers who might be participating in countermeasure activities. This deliverable will contribute to risk mitigation because potential countermeasures for the VIIP syndrome will become more apparent as the syndrome's etiology is better understood.

Internal Customers:
None External Customers:
None

Mappings

Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

SANS-102: Determine the relationship between the fluid-shifts induced ocular changes and fluid shifts in the CNS, including whether elevated intracranial pressure or brain edema play a role.

Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)

Related Tasks (101)

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)