HRR - Task - Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)

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Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry
Principal Investigator: Williams, Michael

Short Title: Direct ICP

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Space Medicine Medical Operations (SMMO)

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

Specific Aim 1: Determine whether ICP in space is elevated in comparison to baseline ICP on Earth, and whether ICP after return to Earth differs from baseline values by measuring ICP in astronauts before, during, and after an ISS mission by invasive methods.

Specific Aim 2: Validate noninvasive ICP measurement methods and their correlation with invasive ICP before, during, and after spaceflight, and to quantify their error of measurement.

Specific Aim 3: Determine the correlation of ICP changes to other indicators of VIIP by collecting biomarkers of VIIP for correlation to ICP.

In addition to opening pressures, blood, urine, and cerebrospinal fluid (CSF) will be collected for biochemical and cytological analyses, including biomarkers unique to elevated ICP and choroid plexus and white matter damage. This study will be performed in conjunction with Zanello's "Multimodal Modeling towards Noninvasive Assessment of Intracranial Pressure in Weightlessness and Biomarker Identification of Predisposition to VIIP Syndrome."

Resources (Flight)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
The deliverable will be a report summarizing a combination of: the dynamics of intracranial pressure during spaceflight, its response to various countermeasures (if applicable), and unique biomarkers in long-duration crewmembers. This report will contribute to VIIP 1 knowledge gap closure by reporting pre-, in-, and postflight intracranial pressure values for long duration crew members. The report might contribute to the VIIP 13 knowledge gap by providing an evaluation of countermeasure efficacies because data will be collected from crewmembers who might be participating in countermeasure activities. This deliverable will contribute to risk mitigation because potential countermeasures for the VIIP syndrome will become more apparent as the syndrome's etiology is better understood.

Internal Customers:
None External Customers:
None

Mappings

Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS-101: Determine the relationship between fluid shifts (intravascular, interstitial, CSF) and ocular manifestations in astronauts during spaceflight.

SANS-102: Determine the relationship between the fluid-shifts induced ocular changes and fluid shifts in the CNS, including whether elevated intracranial pressure or brain edema play a role.

Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)