Task Zero G and ICP: Invasive and Noninvasive ICP Monitoring of Astronauts on the ISS (Williams)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Direct ICP
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Space Medicine Medical Operations (SMMO)
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):

Specific Aim 1: Determine whether ICP in space is elevated in comparison to baseline ICP on Earth, and whether ICP after return to Earth differs from baseline values by measuring ICP in astronauts before, during, and after an ISS mission by invasive methods.

Specific Aim 2: Validate noninvasive ICP measurement methods and their correlation with invasive ICP before, during, and after spaceflight, and to quantify their error of measurement.

Specific Aim 3: Determine the correlation of ICP changes to other indicators of VIIP by collecting biomarkers of VIIP for correlation to ICP.

In addition to opening pressures, blood, urine, and cerebrospinal fluid (CSF) will be collected for biochemical and cytological analyses, including biomarkers unique to elevated ICP and choroid plexus and white matter damage. This study will be performed in conjunction with Zanello's "Multimodal Modeling towards Noninvasive Assessment of Intracranial Pressure in Weightlessness and Biomarker Identification of Predisposition to VIIP Syndrome."