Short Title:
Mechanical Countermeasures - Marketed Devices
Responsible HRP Element:
Human Health Countermeasures
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Collaborating Org(s):
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| Human Health Countermeasures (HHC) Element |
| National Space Biomedical Research Institute (NSBRI) |
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Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
The objective is to test two qualitatively distinct countermeasures (CMs) for VIIP, based on the
assumption that VIIP is caused—or influenced—by cephalad fluid shifts. Studies will be
conducted at MGH as well as at Baylor College of Medicine/NSBRI Center for Space Medicine.
Aim 1: Identify and characterize cerebrovascular and/or ophthalmological parameters altered
by cephalad fluid shifts that are mitigated by mechanical countermeasures.
Aim 2: Identify and characterize any rebound effects or other adverse occurrences when use of
the mechanical countermeasure device is discontinued.
Aim 3: Quantify the effect of two mechanical countermeasures on their ability to reduce
invasively-measured continuous ICP.
Aim 4: Determine if gradual CM discontinuation is safer than abrupt discontinuation.
Aim 5: Quantify the relationship between CM exposure time vs. ICP reduction (and rebound).
Other Resources
| Other Resources Needed?
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Yes
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Category:
Countermeasure
Subcategory:
Protocol
Description:
The deliverable for this task will be a final report detailing summarizing findings. It will contribute to gap closure by informing the efficacy of the countermeasures evaluated.
Internal Customers:
Human Health Countermeasures
External Customers:
None