Task Venous Congestion Countermeasure Study (Marshall-Goebel)
Last Published:  04/20/22 11:43:24 AM (Central)
Short Title: VCCM
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):

The purpose of this proposal is to determine which individual or combination of countermeasures (CMs) most effectively acutely reverses the headward fluid shift and if it is possible to sustain the effects for up to 4 hours.


Specific Aims:


  1. Determine if a single or combination of mechanical countermeasures, including lower body negative pressure (LBNP), veno-constrictive thigh cuffs (VTC), and breathing through an impedance threshold device (ITD), will acutely reverse a seated-to-supine posture headward fluid shift and sustain it for up to 30 min. Outcomes will include noninvasive measures of intracranial pressure (ICP), internal jugular vein cross sectional area (IJVA), internal jugular vein cross sectional pressure (IJVP), choroid thickness, and intraocular pressure.

  2. Determine if the most effective combination of CMs to reverse vascular outcomes in specific aim #1 also reverses the cerebral spinal fluid (CSF) shift by quantifying intraventricular volumes using magnetic resonance imaging (MRI).

  3. Determine if up to 8 hours of daily LBNP during sleep can prevent the headward fluid shift-induced changes during 3 days of head-down tilt bedrest.