Task Microgravity-driven Optic Nerve/Sheath Remodeling Simulator [OPHTHALMIC CHANGES MODELING/ETHIER] (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: Ophthalmic Changes Modeling
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

1. Develop validated tools for computing IOP and ICP in microgravity. These tools will be based on modeling of fluid shifts between the eye and various compartments in the cardiovascular, cerebrospinal and lymphatic systems.

2. Develop validated finite element-based tools for computing the biomechanical environment and subsequent connective
tissue remodeling in the optic nerve head, optic nerve sheath and posterior globe. These tools will be complemented by a model of the eye's optical performance.

3. Integrate the models from Aims 1 and 2 to produce a unified, open and extensible software
package that can predict ocular biomechanics and ocular connective tissue remodeling under microgravity conditions.

4. Use th
e integrated model of Aim 3 to study clinically observable attributes and determine the role they may play in the development of VIIP.

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