HRR - Task - Delivery of Probiotics in the Space Food System

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Delivery of Probiotics in the Space Food System (Completed)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry
Principal Investigator: Douglas, Grace

Short Title: Probiotic Delivery

Responsible HRP Element: Space Human Factors and Habitability

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:
Given the increasing evidence supporting a beneficial relationship between consumption of probiotic bacteria, immunostimulation, and health, an optimal delivery system for probiotics should be determined for spaceflight, where lack of refrigeration limits shelf life and precludes the use of traditional food delivery methods.

Aims: Determine the viability of Lactobacillus acidophilus that is added to non-fat dry milk and rehydrated prior to consumption or provided in a capsule through eight months of storage at -80ºC, 4ºC, and 22ºC and exposure to simulated digestion conditions.

This task is a joint effort between AFT and AEH

Resources (None Listed)

Deliverables (1)

Category: Study Results
Subcategory: Customer Requested Study or Analysis

Description:
The final report contributes to gap closure and risk mitigation by characterizing methods to stabilize and deliver beneficial food substrates (probiotics) by providing storage condition and food delivery recommendations, as well as the viability expectation over storage and during consumption.

Internal Customers:
Space Human Factors and Habitability
External Customers:
SMOD - Space Medicine Operations Division

Is a Customer-Supplier Agreement (CSA) Required? No

Mappings

Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Micro-202: Evaluate the contribution of changes in microbial numbers, types, and virulence on the likelihood and consequence of non-infection-based effects on health and performance, including: decrease in cognition/mood/performance/blood-brain barrier (BBB) function related to the change in the gut’s microbiome and gut-brain axis, increase in cardiovascular health risks, effects of change in gut microbiome on metabolism of nutrients, and correlation with inflammation.

Micro-401: Test, optimize and validate existing terrestrial or novel technologies that can maintain in-flight microbial counts, types, and virulence at terrestrial equivalent levels.

Delivery of Probiotics in the Space Food System

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Risk Approach Plans (2)

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Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-202: Evaluate the contribution of changes in microbial numbers, types, and virulence on the likelihood and consequence of non-infection-based effects on health and performance, including: decrease in cognition/mood/performance/blood-brain barrier (BBB) function related to the change in the gut’s microbiome and gut-brain axis, increase in cardiovascular health risks, effects of change in gut microbiome on metabolism of nutrients, and correlation with inflammation.
	Micro-401: Test, optimize and validate existing terrestrial or novel technologies that can maintain in-flight microbial counts, types, and virulence at terrestrial equivalent levels.