Task Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers (Thiol Mod-Berkowitz, Completed) (Completed)
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Thiol Mod
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:

SA1: To identify a set of differential vascular and then circulating oxidative protein modifications (OPTMS) in a mouse model of radiation induced vascular injury, and flown.

SA2a: To determine whether these modified peptides are associated with impaired coronary endothelial function in mice.

SA2b: To determine whether these modified peptides are associated with impaired coronary endothelial function in flown Astronauts.

SA3: To determine whether Xanthine Oxidase inhibition can alter OPTM proteomic signatures and attenuate endothelial dysfunction.

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