HRR - Task - The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed)

NASA Logo Human Research Roadmap HRP Exploration Data

Evidence MDRP Risks Gaps Tasks Reports

Explore Search

- CV8
- CVD-101
  - CVD

The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed) (Completed)

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Khera, Amit

Short Title: CHARM

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Specific Aim 1: To develop an integrated cardiovascular (CV) risk calculator that incorporates Framingham risk factor variables and coronary artery calcium (CAC) scores. The CV risk calculator will combine risk factor data, CAC scores, and clinical outcomes from three multi-ethnic, population-based cohorts: (1) the Dallas Heart Study, (2) Multi-ethnic Study of Atherosclerosis (MESA), and (3) Prospective Army Coronary Calcium (PACC) study.

Specific Aim 2: To determine if C-reactive protein and/or family history of coronary disease modify CV risk estimates in the integrated Framingham risk score (FRS)/CAC calculators.

Resources (None Listed)

Deliverables (1)

Category: Technology or Tool
Subcategory: Computational Models or Simulations

Description:
TRL8 – Tool that is an integrated CV risk calculator that incorporates Framingham risk factor variables and CAC scores.

Internal Customers:
None External Customers:
Med Ops - Medical Operations

Is a Customer-Supplier Agreement (CSA) Required? No

Mappings

Risk of Spaceflight Induced Cardiovascular Disease

CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed)

Related Tasks (112)

Print View...

Risk Approach Plans (1)

NASA Developer: Daniel Febus Responsible NASA Official: Susan Torney Contact HRP for a 508 compliant PDF Budgets, Strategic Plans, and Accountability Reports Equal Employment Opportunity Data Posted Pursuant to the No Fear Act Information-Dissemination Policies and Inventories Freedom of Information Act President's Management Agenda Privacy Policy & Important Notices Inspector General Hotline Contact HRP Human Health and Performance DIR Johnson Space Center USA.gov ExpectMore.gov

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.