HRR - Task - The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed)

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The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed) (Completed)

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: Khera, Amit

Short Title: CHARM

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Specific Aim 1: To develop an integrated cardiovascular (CV) risk calculator that incorporates Framingham risk factor variables and coronary artery calcium (CAC) scores. The CV risk calculator will combine risk factor data, CAC scores, and clinical outcomes from three multi-ethnic, population-based cohorts: (1) the Dallas Heart Study, (2) Multi-ethnic Study of Atherosclerosis (MESA), and (3) Prospective Army Coronary Calcium (PACC) study.

Specific Aim 2: To determine if C-reactive protein and/or family history of coronary disease modify CV risk estimates in the integrated Framingham risk score (FRS)/CAC calculators.

Resources (None Listed)

Deliverables (1)

Category: Technology or Tool
Subcategory: Computational Models or Simulations

Description:
TRL8 – Tool that is an integrated CV risk calculator that incorporates Framingham risk factor variables and CAC scores.

Internal Customers:
None External Customers:
Med Ops - Medical Operations

Is a Customer-Supplier Agreement (CSA) Required? No

Mappings

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CV-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

The Development of a NASA/NSBRI Risk Calculator to Estimate the Short Term Risk of an Acute Coronary Event in Astronauts (CHARM-Khera, Completed)

Related Tasks (119)

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes
	CV-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.