Short Title:
SR Stem Vascular Cardiac
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
The integrity of organs and tissues is maintained through continued cell production to replace damaged or senescent cells. In particular stem cells are pivotal to this process providing the primary source for production of functional cells. In the heart, cardiac stem cells (CSCs) reside in close proximity to stromal cells or mesenchymal stem cells (MSCs) that produce proteins that control the growth and development. Stem cells are quiescent cells that cycle through self-replication very slowly. This decreases the ability of these cells to repair damage to DNA and may lead to increased risks of vascular and heart disease. In this application we will evaluate the effects of exposure of stem cells to spaceflight-relevant radiation.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Final Report on models of stem cell damage
Internal Customers:
None
External Customers:
None