Funding Status:
Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
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Aims:
Aim 1: Determine, as a function of radiation dose, acute, radiation-induced atherosclerosis is associated changes in gene and protein expression in aortic endothelial cells of irradiated mice.
Aim 2: Determine, as a function of radiation dose, changes in oxidation states of aortic endothelial cell lipids.
Aim 3: Determine the dose dependence of functional consequences of 56Fe, and protons with respect to perturbations in endothelial reactivity and aortic adhesivity.
Aim 4: Develop a systems biology model of response of aortic endothelial cells to radiation damage to determine molecular mechanisms.