HRR - Task - Radiation-Induced Early Changes in Gene and Protein Expression, Lipid Oxidative States, and Vascular Function Related to Atherosclerosis

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Radiation-Induced Early Changes in Gene and Protein Expression, Lipid Oxidative States, and Vascular Function Related to Atherosclerosis (Completed)

Last Published: 03/26/21 03:34:00 PM (Central)

Task Book: Entry
Principal Investigator: Kabarowski, Janusz

Short Title: SR Vascular Atherosclerosis

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Aim 1: Determine, as a function of radiation dose, acute, radiation-induced atherosclerosis is associated changes in gene and protein expression in aortic endothelial cells of irradiated mice.

Aim 2: Determine, as a function of radiation dose, changes in oxidation states of aortic endothelial cell lipids.

Aim 3: Determine the dose dependence of functional consequences of 56Fe, and protons with respect to perturbations in endothelial reactivity and aortic adhesivity.

Aim 4: Develop a systems biology model of response of aortic endothelial cells to radiation damage to determine molecular mechanisms.

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Evidence on how space radiation may induce early changes in endothelial cell genes, proteins, and lipids that cause vascular dysfunction and how these changes may predictive of the risk of cardiovascular disease. Evidence will be documented in annual and final reports and support the closure of Degenerative Gaps 1 and 2.

Internal Customers:
None External Customers:
None

Mappings

Risk of Spaceflight Induced Cardiovascular Disease

CVD-102: Determine whether space radiation induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Radiation-Induced Early Changes in Gene and Protein Expression, Lipid Oxidative States, and Vascular Function Related to Atherosclerosis

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Risk Approach Plans (1)

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Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease