Task Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: SR Degenerative CNS
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

(1) Characterize the hippocampal and CP histopathology and molecular functions predicted by the ‘omics surveys of HZE-irradiated animals with the emphasis on tissue abnormalities that occur in AD;

(2) Investigate the molecular mechanisms of inter individual variations in neuro-cognitive performance (i.e., susceptibility) following HZE radiation using glycoproteomics, metabolomics and in situ validation; and

(3) Characterize the radiation sensitivity of persistent CP epithelial and endothelial damage in AD mouse models and examine their associations with neuro-inflammation. This research is foundational to establish quantitative mechanism-based predictors for neuro-cognitive risks and onset of AD symptoms in individuals exposed to high-LET space radiation.

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Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
You are here!TaskMolecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
You are here!TaskMolecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation