HRR - Task - Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation

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Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation (Completed)

Last Published: 07/31/19 10:05:33 AM (Central)

Task Book: Entry
Principal Investigator: Wyrobek, Andrew

Short Title: SR Degenerative CNS

Responsible HRP Element: Space Radiation

Collaborating Org(s):

Other:

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

(1) Characterize the hippocampal and CP histopathology and molecular functions predicted by the ‘omics surveys of HZE-irradiated animals with the emphasis on tissue abnormalities that occur in AD;

(2) Investigate the molecular mechanisms of inter individual variations in neuro-cognitive performance (i.e., susceptibility) following HZE radiation using glycoproteomics, metabolomics and in situ validation; and

(3) Characterize the radiation sensitivity of persistent CP epithelial and endothelial damage in AD mouse models and examine their associations with neuro-inflammation. This research is foundational to establish quantitative mechanism-based predictors for neuro-cognitive risks and onset of AD symptoms in individuals exposed to high-LET space radiation.

Resources (None Listed)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
Evidence on how space radiation induces persistent morphological and functional damage to the choroid plexus and defective hippocampal neurogenesis and how the magnitude of these defects can be predictive of individual sensitivity for CNS risks of neurocognitive deficits. Evidence will be documented in annual and final reports and support the closure of CNS gaps 2 and 3.

Internal Customers:
None External Customers:
None

Mappings

Risk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure

CBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?

CBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?

Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation

Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

BMed9: We need to understand long term astronaut health for long duration exploration missions and find the best methods to promote long term post-mission behavioral health.

Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation

Related Tasks (423)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders