Task Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: HZE Neuroproteome- CBS Supplement (Britten)
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other:
Space Radiation (SR) Element
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:
Original HZE Neuroproteome Task was completed by SR in 2019, and a CBS Supplement awarded to explore the Sex Differences as an add-on to the original aims.

Aim 1. Determine the Threshold dose for the induction of HISMI and HIASSI following exposure to 56Fe, 48Ti, and 28Si particles when delivered as a single dose.

Aim 2. Determine the Threshold dose for the induction of HISMI and HIASSI following exposure to 56Fe, 48Ti, and 28Si particles when delivered in three fractions over a 5-day period.

Aim 3. Identify changes in the neuroproteome that are associated with susceptibility or resistance to developing HISMI and HIASSI following exposure to 56Fe particles.

Aim 4. Determine the mechanism of HISMI and HIASSI induced by HZE particles of differing LET.


CBS Supplement Aim 1: Establish the impact that that re-irradiation with 10 cGy of simplified (5-ion) CGRsim beam has on the ATSET performance of male Wistar rats that maintained a functional ATSET performance after exposure to 10 cGy of either He or GCRsim.
CBS Supplement Aim 2: Establish the impact that that re-irradiation with 10 cGy of simplified (5-ion) CGRsim beam has on the ATSET performance of female Wistar rats that maintained a functional ATSET performance after exposure to 10 cGy of either He or GCRsim.
Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCNS - 6: How can new knowledge and data from molecular, cellular, tissue and animal models of late CNS risks or clinical human data be used to estimate late CNS risks to astronauts from GCR and SPE?
You are here!TaskChanges in the Neuroproteome Associated with HZE-Induced Impairment of Cognition

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapCBS-BMed3: We need to identify and quantify the key threats to and promoters of mission relevant behavioral health and performance during autonomous, long duration and/or long distance exploration missions.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
You are here!TaskChanges in the Neuroproteome Associated with HZE-Induced Impairment of Cognition