HRR - Task - Effect of low shear modeled microgravity (LSMMG) on the probiotic Lactobacillus acidophilus ATCC 4356

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Effect of low shear modeled microgravity (LSMMG) on the probiotic Lactobacillus acidophilus ATCC 4356 (Completed)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Douglas, Grace

Short Title: LSMMG Probiotic

Responsible HRP Element: Space Human Factors and Habitability

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:
Determine the effects of LSMMG culture on the growth, stress response, and transcriptomic profile of L. acidophilus ATCC 4356.

Will contribute to AEH and Immune.

Resources (None Listed)

Deliverables (1)

Category: Countermeasure
Subcategory: Clinical Procedure/Prescription

Description:

The final deliverable was a report that showed evidence that LSMMG culture does not impact the growth, stress response, and gene expression of L. acidophilus. The deliverable contributed to gap closure and risk mitigation by characterizing a probiotic's response to a spaceflight analogue environment, indicating that for this probiotic characteristics are consistent with Earth-based culture and benefits may be expected to transfer to spaceflight. Investigation of more strains in future would define strain selection criteria for spaceflight.

Internal Customers:
Space Human Factors and Habitability
External Customers:
None

Mappings

Risk of Adverse Health Effects Due to Host-Microorganism Interactions

Micro-202: Evaluate the contribution of changes in microbial numbers, types, and virulence on the likelihood and consequence of non-infection-based effects on health and performance, including: decrease in cognition/mood/performance/blood-brain barrier (BBB) function related to the change in the gut’s microbiome and gut-brain axis, increase in cardiovascular health risks, effects of change in gut microbiome on metabolism of nutrients, and correlation with inflammation.

Micro-401: Test, optimize and validate existing terrestrial or novel technologies that can maintain in-flight microbial counts, types, and virulence at terrestrial equivalent levels.

Effect of low shear modeled microgravity (LSMMG) on the probiotic Lactobacillus acidophilus ATCC 4356

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Risk Approach Plans (2)

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Common Item(s)
	Risk of Adverse Health Effects Due to Host-Microorganism Interactions
	Micro-202: Evaluate the contribution of changes in microbial numbers, types, and virulence on the likelihood and consequence of non-infection-based effects on health and performance, including: decrease in cognition/mood/performance/blood-brain barrier (BBB) function related to the change in the gut’s microbiome and gut-brain axis, increase in cardiovascular health risks, effects of change in gut microbiome on metabolism of nutrients, and correlation with inflammation.
	Micro-401: Test, optimize and validate existing terrestrial or novel technologies that can maintain in-flight microbial counts, types, and virulence at terrestrial equivalent levels.