Task Impact of Space Radiation on Cognition, Synapses and Biomarkers in Aging and Alzheimer's Disease (Completed)
Last Published:  07/31/19 10:05:33 AM (Central)
Short Title: Cognition and Biomarkers in AD
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Other:
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Solicited
Aims:

The specific aims of this study are:

 

Aim 1.  Determine the gender-specific early and late effects of space radiation on cognition, synaptic changes, Alzheimer’s Disease (AD) pathogenesis, cerebral blood flow (CBF) and neuroinflammation (GE180 PET) in a well-characterized Alzheimer’s Tg mouse model bearing 2 familial mutations (APPswe and PS1dE9) associated with early-onset AD and strain-, age, and gender-matched C57BL/6 WT mice. 

 

Aim 2.  Comparison of the effects of a single dose versus fractionated irradiation with 1000 MeV/μ 56 Fe ions on cognition and locomotion, as well as changes in cerebral blood flow, brain volume, neuroinflammation, synapses, AD pathogenesis and neuron loss.

Resources (None Listed)
Mappings
RiskRisk of Acute (In-flight) and Late Central Nervous System Effects from Radiation Exposure
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
GapCNS - 6: How can new knowledge and data from molecular, cellular, tissue and animal models of late CNS risks or clinical human data be used to estimate late CNS risks to astronauts from GCR and SPE?
You are here!TaskImpact of Space Radiation on Cognition, Synapses and Biomarkers in Aging and Alzheimer's Disease

RiskRisk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
GapBMed9: We need to understand long term astronaut health for long duration exploration missions and find the best methods to promote long term post-mission behavioral health.
GapCBS-CNS - 1: Are there significant adverse changes in CNS performance in the context and time scale of spaceflight operations? If so, how is significance defined, and which neuropsychological domains are affected? Is there a significant probability that space radiation exposure would result in adverse changes? What are the pathways and mechanisms of change?
GapCBS-CNS - 2: Does space radiation exposure elicit key events in adverse outcome pathways associated with neurological diseases? What are the key events or hallmarks, their time sequence and their associated biomarkers (in-flight or post-flight)?
GapCBS-CNS - 3: How does individual susceptibility including hereditary pre-disposition (e.g. Alzheimer’s, Parkinson’s, apoE allele) and prior CNS injury (e.g. concussion, chronic inflammation or other) alter significant CNS risks? Does individual susceptibility modify possible threshold doses for these risks in a significant way?
You are here!TaskImpact of Space Radiation on Cognition, Synapses and Biomarkers in Aging and Alzheimer's Disease