HRR - Task - Workload and Scheduling Tools for Long Duration Missions (Research Requirements)

Robust Human-System Interface Design for Spaceflight-Induced Environments (Interface Design-Stone, Completed)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Information Presentation – Displays Development (Visual and Auditory)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Information Presentation – Controls Technology Survey and Testing

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Information Presentation - Electronic Procedures and Fault Management

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Information Presentation – Human Performance Modeling

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Spaceflight Resource Management Training

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Medical Proficiency Training

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Modeling and mitigating spatial disorientation in low g environments

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Enhancement of Spatial Orientation Capability of Astronauts on the Lunar Surface

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Sensorimotor Displays and Controls to Enhance the Safety of Human/Machine Cooperation During Lunar Landing (Lander D&C-Young, Completed)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Advanced Displays for Efficient Training and Operation of Robotic Systems (Robotic Systems-Oman, Completed)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Just in Time Simulation Platform

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Displays and Controls Interfaces

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Assessing and Mitigating the Impact of Transmission Delays on Teleoperations

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Automation Interface Design Tools Development

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Assessment, evaluation, and development of methodologies, metrics, and tools available for use in multi-agent (human and robotic) teaming

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Human – Automation Interactions and Performance Analysis of Lunar Lander Supervisory Control

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Space Human Factors and Habitability MIDAS-FAST: Development and Validation of a Tool to Support Function Allocation

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Needs Assessment and Work Allocation Tools for Mission Operations and Procedures

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Usability Evaluation

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Workload Tools and Guidelines

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Spaceprint: Development and Validation of a Tool to Predict, Evaluate, and Mitigate Excessive Workload Effects

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Semantic Language and Tools for Reporting Human Factors Incidents

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

SDBI 1904 - Human Factors Assessment of Vibration Effects on Visual Performance During Launch

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Combined whole-body vibration plus G-loading influences on visual performance and operator ratings

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Spinal Elongation and its Effects on Seated Heights in a Microgravity Environment

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Space Craft Internal Acoustic Environment

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Habitability-Human Factors and Habitability Assessment Tool

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Space Radiation Risk Assessment Project-Cucinotta

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Sensory Stimulation Augmentation Tools (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Hybrid Training - A Sensory Stimulation Countermeasure for Long Duration Space Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Psychomotor Vigilance Test (PVT) on ISS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Promoting behavioral health, cognitive, sensorimotor and immune function using guided imagery to augment exercise training in an isolated and confined spaceflight analog environment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Objective Detection, Evaluation and Countermeasures for In-flight Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Optical Computer Recognition of Stress, Affect and Fatigue During Performance in Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Objective Monitoring of Crew Neurobehavioral Functions (105-day Russian Chamber Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Neurobehavioral Conditions List for Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Asthenia Literature Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Voice Content Analysis Techwatch

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Detection & Prevention of Neurobehavioral Vulnerability to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evidence Review: Cognition in Long Duration Missions in Isolated, Confined and Extreme Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Validation of Assessment Tests and Countermeasures for Detecting and Mitigating Changes in Cognitive Function During Robotics Operations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Integrated Cognitive Assessment: Combining Measurement, System, and Mission

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Neurostructural, Cognitive, and Physiologic Changes During a 1-year Antarctic Winter-Over Mission

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Cognitive Performance and Stress in a Simulated Space Environment

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

The Prediction of the Onset of Anxiety Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

White Paper on the Onset of Depression

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Meta-Analysis of the effects of ICE environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Evidence Review on Identification of Psychosocial Characteristics in ICE Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Growth and Resilience for Long Duration Exploration Missions(RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Well-Being on Performance in ICE Environments (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individual differences and adaptation to Isolated, Confined, and Extreme (ICE) environments (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Self-Guided Depression Treatment on Long-Duration Spaceflights

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Multi-Media, Computer-Based, Self-Directed, Autonomous, Stress and Anxiety-Management Countermeasure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Behavioral Issues Associated with Long Duration Space Missions: Review of Astronaut Journals

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Asynchronous Behavioral Health Treatment Techniques

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Immune Function Data Mining

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Sleep-Wake Actigraphy and Light Exposure During Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Environmental Factors Evidence Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Transition Actiwatch Protocol to Medical Operations

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

The Biological Basis of Emotional Support for Long Duration Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Determine best methods to maintain contact with astronaut social support network during pre-mission training (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Techwatch for Sleep Monitoring Technologies for Long Duration Spaceflight

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload

Evidence Review on Biomarkers of Individual Vulnerabilities to Sleep Loss and Circadian Desynchronization

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

AD ASTRA: Automated Detection of Attitudes and States through Transaction Recordings Analysis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Team Risk Standardized Measures Workshop

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Operational Evaluation of Photic Countermeasure to Improve Alertness, Performance, and Mood during Nightshift Work on a 105-Day Study (105-day Russian Chamber Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Countermeasure for Managing Interpersonal Conflicts in Space: A Continuation Study

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Serious Games for Team Training

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

ANSIBLE: A Network of Social Interactions for Bilateral Life Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Dynamic Team Role Allocation in Long Duration, Exploration Missions: Identification of Roles, Triggers, and Measurement Tools

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optimizing Light for Long Duration Space Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Blue Light for Enhancing Alertness in Space Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Facilitating the Synergistic Side of Cultural Diversity in LDSE: Identification of Challenges and Development of Cultural Training

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Crew Scheduling Tools

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-501: We need to determine how HSI will be used in the development of dynamic and adaptive mission procedures and processes, to mitigate individual and team performance decrements during increasingly earth-independent, future exploration missions (including in-mission and at landing).

Feasibility Pilot Study on Acute Biological and Behavioral Responses to the Solid State Lighting Modules for the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Testing solid state lighting countermeasures to improve circadian adaptation, sleep, and performance during high fidelity analog and flight studies for the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Develop and Implement Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects (pilot study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Operational Ground Testing Protocols to Individualize Astronaut Sleep Medication Efficacy and Individual Effects

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Designing Individual Countermeasures to Reduce Sleep Disruption and Improve Performance and Alertness in Space

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Physiologically-Based Modeling of Sleep-Wake Scheduling and the Effects of Pharmaceuticals (NSBRI Postdoctoral Fellowship)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Countermeasures for Performance Deficits from Sleep Loss and Workload in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Individualized Fatigue Meter for Space Exploration (SBIR Phase II)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Countermeasures to Neurobehavioral Deficits from Cumulative Sleep Deprivation During Space Flight: Dose-Response Effects of Recovery Sleep Opportunities

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Survey of On-Orbit Sleep Quality (Sleep Quality Questionnaire)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Phoenix Scout Lander: Countermeasures Testbed for Spaceflight Ground Controllers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

A Comprehensive Fatigue Management Program and an Evaluation of a Photic Countermeasure for Mission Controllers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurodegeneration and Adaptation in Response to Low-Dose Photon Irradiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Proteomic aided investigation of the mechanistic basis for HZE-induced cognitive impairment and the development of diagnostic biomarkers

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

The Impact of HZE Particles on Adult Neural Stem Cells and Neurogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Epigenetic Control of Radiogenic Damage Processing in C. elegans

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Molecular Basis of DNA Repair and Protection from Apoptosis in Neuronal Progenitors Exposed to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Local CNS and Systemic Inflammatory Effects Following Proton and Mixed Particle Exposure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Oxidative stress as a mechanism for altering acute and chronic functional changes in the CNS exposed to low dose, low dose rates, and mixed fields of protons and HZE nuclei

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Use of a molecular marker of learning and memory to assess effects of 56Fe irradiation on hippocampus-dependent cognition and neurogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Cognitive/Behavioral, Sensory, & Motor Changes Induced by Solar Particle Event (SPE) and Galactic Cosmic Ray (GCR) Irradiations

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

NSCOR: Charged Particle Radiation and Resultant Oxidative Stress Elicit Deleterious Functional Changes in the Central Nervous System

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Development and use of human 3-Dimensional tissue culture models for the study of space radiation effects on the central nervous system

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Virtual Reality (VR) Technologies for Enhancing Behavioral Health

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Assessing Team Performance in Autonomous Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Alphalipoic Acid on Irradiation Induced Cognitive Deficits (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Individualized Real-Time Neurocognitive Assessment Toolkit for Space Flight Fatigue

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Composing and Developing Resilient, Adaptive, and Self-Sustaining Teams for Long Duration Space Exploration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Spaceflight Effects on Neurocognitive Performance: Extent, Longevity, and Neural Bases (NeuroMapping-Flight-Seidler)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Evidence-based Metrics Toolkit for Measuring Safety and Efficiency in Human-Automation Systems

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Human Factors Analysis Support Tool (H-FAST)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Computational Model for Spacecraft/Habitat Volume

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Electronic Procedures for Crewed Missions Beyond Low Earth Orbit (LEO)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-501: We need to determine how HSI will be used in the development of dynamic and adaptive mission procedures and processes, to mitigate individual and team performance decrements during increasingly earth-independent, future exploration missions (including in-mission and at landing).

Two-Hit Model of Alzheimer's Disease

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Functional decline in mice with Alzheimer's-type neurodegeneration is accelerated by charge-particle radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Molecular Characterization of Long-term Degenerative CNS Risks from Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Identification of the Changes in the Brain Proteome Associated with HZE-induced Neurocognitive Impairment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Multi-Modal Neurodiagnostic Tool for Stress Monitoring

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Individualized Stress Detection System

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Sleep Workshop

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Development and testing of biomarkers to determine individual astronauts' vulnerabilities to behavioral health disruptions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Individualized Behavioral Health Monitoring Tool

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Objective Monitoring of Crew Neurobehavioral Functions in Mars 520-Day Simulation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

CogGauge Enhancement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

South Pole Station: An Analogue for Human Performance During Long Duration Missions to Isolated and Confined Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Stress, Affect and Fatigue in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Self-Guided Multimedia Stress Management and Resilience Training

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Autonomous Behavioral Health Countermeasures for Spaceflight - Virtual Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Characterize Workload on the International Space Station (ISS) (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Effects of Space Radiation on Hippocampal-Dependent Learning and Neuropathology in Wild-Type and Alzheimer's Disease Transgenic Mice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Effects of Space Radiation on the Function of Human Brain Capillaries and the Blood-brain-barrier: Implications for Neurodegenerative Disorders

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Molecular and Cellular Mechanisms of Space Radiation-Induced Changes in Hippocampal-Dependent Behavior

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Android App Incorporating the PVT to deliver individualized Fatigue Risk Management in Commercial Trucking

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Impact of Space Radiation Induced Neuroinflammation on Alzheimer and Parkinson Disease Pathology

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Inflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Mechanisms of high LET radiation induced genomic instability in the CNS - UC Irvine Grant

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

NSCOR: Progressive Alterations of Central Nervous System Structure and Function Are Caused by Charged Particle Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Neurogenesis and cognition in human apoE transgenic mice following 56Fe radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Speech monitoring of cognitive deficits and stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Low Dose Ionizing Radiation and HZE Particle Effects on Adult Hippocampal Neurogenesis: A Sensitive Indicator of CNS Microenvironmental Changes

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Dose-rate and mixed field effects of protons and HZE nuclei on oxidative injury and stem cell plasticity in the CNS

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Replacement Lighting for Research and Training

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Neurochemical and Behavioral Effects of Exposure to Heavy Particles -- NNJ06HD93G

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Mathematical Modeling of Circadian/Performance Countermeasures

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

A Model of Circadian Disruption in the Space Environment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Optical Computer Recognition of Performance Under Stress

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Development of a User Interface for the PVT SelfTest (PST)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Impact of HZE Particles Exposure on Proliferation and Differentiation of Human Neural System Cells

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

HZE Radiation Effects On Neuroinflammation: Role Of Cox-2

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Assessing the Impact of Communication Delay on Performance: An Examination of Autonomous Operations Utilizing the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Training Needs Analysis

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Selection Studies Retrospective

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Net Habitable Volume Community of Practice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Protocols for Asynchronous Communication in Space Operations: Communication Analysis

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Ultra-Short Light Pulses as Efficient Countermeasures for Circadian Misalignment and Objective Performance and Subjective Alertness Decrements

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

The ISS Dynamic Lighting Schedule: An in-flight lighting countermeasure to facilitate circadian adaptation, improve sleep and enhance alertness and performance on the International Space Station

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Automation in Procedures: Guidelines for Allocating Tasks for Performance

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Markers of Susceptibility to Neurobehavioral Decrements in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Detection and Prevention of Neurobehavioral Vulnerability to Space Radiation II

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Bed Rest as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases (Seidler)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Developing Predictive Measures of Sensorimotor Adaptability to Produce Customized Countermeasure Prescriptions (Bloomberg)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Quantification of In-flight Physical Changes - Anthropometry and Neutral Body Posture (NBP)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

High LET-radiation induced DNA repair mechanisms in Oligodendrocyte progenitor cells (OPC) in vitro and in vivo - CCSB

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Charged Particle Effects on Neuronal Injury, Plasticity and Neurodegeneration

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Individual Differences in the Neurochemical and Behavioral Response to Exposure to Protons and HZE Particles

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Effects of Space Radiation on Long Term Synaptic Plasticity and Neurogenesis in Normal and Alzheimer's Disease Transgenic Mice

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

The Relation Between Cognitive Injury, Network Stability, and Epigenetic Change Following Exposure to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Automatic Video-based Motion Analysis

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Vehicle NHV and Habitability Assessment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Effects of Long-duration Microgravity on Fine Motor Control Skills

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Display Reading Performance Under Lateral Whole-Body Vibration Due to 12-Hz Thrust Oscillation

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Effects of Long-Duration Spaceflight on Training Retention

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Analog investigation of team resilience over time

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Understanding Key Components of Successful Autonomous Space Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Macrocognition in Teams: Examining and Developing Team Cognitive Processes and Products in the Context of Long Duration Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Investigate shifts in team cognitive processes over time (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Investigate shifts in team motivation and morale over time (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Developing and Validating Sensor-based Measurement Strategies for Team Member Selection

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Standardized Behavioral Measures for Detecting Behavioral Health Risks during Exploration Missions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Characterization of Psychological Risk, Overlap with Physical Health, and Associated Performance in Isolated, Confined, Extreme (ICE) Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Effects of Acute Exposures to Carbon Dioxide upon Cognitive Functions

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mindfulness, Recreation, and Relaxation as a Countermeasure for Long Duration Exploration Missions (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Individualized Real-Time Neurocognitive Assessment Toolkit (Cognition) for Space Flight Fatigue (ISS-12) (NSBRI)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Using Real-Time Lexical Indicators to Detect Performance Decrements in Spaceflight Teams: A Methodology to Dynamically Monitor Cognitive, Emotional, and Social Mechanisms that Influence Performance

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Cyber Partners: Harnessing Group Dynamics to Boost Motivation for More Efficient Exercise

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

STARwatch to Deliver Objective Sleep Measures for Spaceflight Operations (SBIR Phase 2)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Lighting Protocols for Exploration - HERA Campaign

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Validation of model predictions of alertness, performance, and sleepiness

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Diet as a sleep/circadian countermeasure (Research Requirements)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Psychomotor Vigilance Test (PVT) on ISS (Reaction Self-Test on ISS-12)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Sleep-Wake Actigraphy and Light Exposure During Spaceflight (ISS-12)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Metrics and Methods for Real-Time Task Performance Assessment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Mechanisms of low dose HZE alteration of neuronal-astrocytic coupling: The role of purinergic receptors and calcium signaling

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Molecular Characterization of Choroid Plexus and Hippocampal Damage and Degenerative CNS Risks from Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Particle Radiation-Induced Dysregulation of Protein Homeostasis in the Brain

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Changes in the Neuroproteome Associated with HZE-Induced Impairment of Cognition

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Acute and long term outcomes of simulated deep space radiation exposure on latent viral CNS infection & CNS pathology

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Impact of Space Radiation on Cognition, Synapses and Biomarkers in Aging and Alzheimer's Disease

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Evaluation of the validity, acceptability and usability of bio-mathematical models to predict fatigue in an operational environment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	HSIA-501: We need to determine how HSI will be used in the development of dynamic and adaptive mission procedures and processes, to mitigate individual and team performance decrements during increasingly earth-independent, future exploration missions (including in-mission and at landing).
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Assess Glymphatic Changes for Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Future Vehicle Environment (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Development of a Software and User Interface to Support Scenario Modeling of Astronaut Schedules to Aid in the Selection of Fatigue Countermeasures within the Behavioral Health and Performance Dashboard (BHP-DS)

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Post-Mission Behavioral Health Conditions Assessment (RR+Datamining)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Social, Family, and Behavioral Health Support NSCOR

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Astronaut Exploration Factors (Data Mining & Whitepaper)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Meaningful Work for Long Duration Exploration Missions (RR)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Human Performance Data Project

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-501: We need to determine how HSI will be used in the development of dynamic and adaptive mission procedures and processes, to mitigate individual and team performance decrements during increasingly earth-independent, future exploration missions (including in-mission and at landing).

Generalizable Skills and Knowledge for Exploration Missions

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-501: We need to determine how HSI will be used in the development of dynamic and adaptive mission procedures and processes, to mitigate individual and team performance decrements during increasingly earth-independent, future exploration missions (including in-mission and at landing).

Speech Alarms Pilot Study

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Biomarkers as Predictors of Resiliency and Susceptibility to Stress in Space Flight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Human Factors Analysis Support Tool (H-FAST) Phase III

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Objective Function Allocation Method for Human-Automation/Robotic Interaction using Work Models that Compute

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Human-automation and Robotic Integration Design Reference Mission Task Scoping

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Human-automation and Robotic Integration Trade Study Analysis

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Multimodal Augmented Displays for Surface Telerobotic Missions

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

A Multi-faceted Approach to Examine Team Adaptation & Resilience within Isolated, Confined, and Extreme Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Project FUSION: Facilitating Unified Systems of Interdependent Organizational Networks

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.
	HSIA-501: We need to determine how HSI will be used in the development of dynamic and adaptive mission procedures and processes, to mitigate individual and team performance decrements during increasingly earth-independent, future exploration missions (including in-mission and at landing).

Multi-Team System (Research Requirements)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Team NHV (Research Requirements)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Team Member/ Vehicle Interaction

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

A Tool for the Automated Collection of Space Utilization Data

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Wearable Kinematic Systems for Quantifying 3-D Space Utilization in the Microgravity Environment

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Semantic Language and Tools for Reporting Human Factors Incidents - Phase III

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Training for Generalizable Skills & Knowledge: Integrating Principles and Procedures

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Crewmember Expectations Training for Long Duration Exploration Missions (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Assessing the Impact of Chronic Sleep Restriction on Sleep and Performance-Associated Regional Brain Activation Using Near-Infrared Spectroscopy (Postdoctoral Fellowship)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Customized Refresher and Just-in-Time Training for Long-Duration Spaceflight Crews (NSBRI, Robinson)

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Monitoring Technologies COTS and NASA Tools Evaluation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

The Impact of Objectively Measured Sleep Deficiency and Circadian Misalignment on Performance During Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Evaluation of Crew-Centric Onboard Mission Operations Planning and Execution Tool

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.
	HSIA-501: We need to determine how HSI will be used in the development of dynamic and adaptive mission procedures and processes, to mitigate individual and team performance decrements during increasingly earth-independent, future exploration missions (including in-mission and at landing).

Cognitive Performance and Crew Cohesion during Confinement in NASA's Human Research Program Human Exploration Research Analog (HERA)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Radiation Exposures in Space and the Potential of Central Nervous System Effects

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Neurobehavioral and CNS-Related Physiological Changes Following Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

HZE particle exposure-induced improvement of pattern separation in mature mice: alterations in mission-relevant behaviors and neural circuitry

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Family Training and Support Research Requirements

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Team Task Switching in Astronaut Crews on the International Space Station: Integrating Multiteam Membership, Multiteam Systems, Multitasking, & Multidimensional Networks to Monitor & Enable Functional Work Shifts in Astronaut Crews

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Understanding and Preventing Crew Member Task Entrainment

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Software Enabled Therapeutics for Psychiatry, Neurology, and Pain

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Cognition Validation Study in High Performing Healthy Controls at Penn

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Mitigating Neurobehavioral Vulnerabilities to Space Radiation (Follow-On Study)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Cognitive Bias and Decision Making Training (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mechanisms Underlying Charged Particle-Induced Disruption of CNS Function

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

NASA Specialized Center of Research on Carcinogenesis

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Late CNS Risk Modeling

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

2022 NSCOR: CVD/Late CNS clinical MCM Assessment

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

2026 NSCOR: CVD/Late CNS MCM Assessment: Combined Spaceflight Stressors

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Team and Sleep Preliminary Literature Review

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Analog Team/Behavioral Medicine Data Mining

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Creating a Taxonomy of Variables Affecting Cognitive Aid via an Investigation of Hybrid Aids

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-501: We need to determine how HSI will be used in the development of dynamic and adaptive mission procedures and processes, to mitigate individual and team performance decrements during increasingly earth-independent, future exploration missions (including in-mission and at landing).

Cognitive Assessment and Prediction to Promote Individualized Capability Augmentation and Reduce Decrement

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Lighting as a Cognitive and Behavioral Health Countermeasure

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Computational Modeling to Limit the Impact Displays and Indicator Lights Have on Habitable Volume Operational Lighting Constraints

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Human-Centered Design in an Agile Process

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Personality and biological predictors of resiliency to chronic stress among high-achieving adults

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Asynchronous Techniques for the Delivery of Empirically Supported Psychotherapies

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Use of Hypnotic and Alertness Medications in Military Populations (Research Requirements)

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Sleep electroencephalography and near-infrared spectroscopy measurements for spaceflight and analogs

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Quantifying and Developing Countermeasures for the Effect of Fatigue-Related Stressors on Automation Use and Trust During Robotic Supervisory Control

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture

Countermeasures for Neurobehavioral Vulnerabilities to Space Radiation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Environmental Factors Associated with Sleep Deficiency During Spaceflight

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Design and Evaluation of Automated Electronic Checklists for Robotics Operations

Common Item(s)
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	HSIA-501: We need to determine how HSI will be used in the development of dynamic and adaptive mission procedures and processes, to mitigate individual and team performance decrements during increasingly earth-independent, future exploration missions (including in-mission and at landing).

Behavioral Issues Associated with Long Duration Space Missions: Review and Analysis of Astronaut Journals - Extension and ISS-12

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Hadron-induced impairment of Executive Function:role of perturbed neurotransmission and the exacerbating impact of sleep deprivation

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Team State Lexical Analysis Software Refinement and Feasibility Testing

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	HSIA-101: We need to identify the Human Systems Integration (HSI) – relevant crew health and performance outcomes, measures, and metrics, needed to characterize and mitigate risk, for future exploration missions.

Individual Differences in the Neuronal and Behavioral Response to Exposure to HZE Particles

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Impact of Space-Radiation Induced Alterations on Toxic Protein Accumulation Associated with Neurodegenerative Disease

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Bed Rest Combined with 0.5% CO2 as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Mars 600/900 Simulation I: Large Animal Chronic Studies

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders

Radiation Exposures in Space and the Potential of Central Nervous System Effects Phase II

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

LumosTech Smart Sleep Mask for Circadian Realignment in Space and on Earth

Common Item(s)
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	Sleep-102: We need to identify and develop an integrated, individualized suite of scheduling tools that predict the effects of sleep-wake cycles and light on performance, with validated countermeasures and on-board systems to monitor, prevent and/or treat chronic partial sleep loss, work overload, and/or circadian shifting in spaceflight.

Real-Time Estimation of the Effects of a Simulated Long-Duration Exploration Mission on Flight Performance, Workload, and Situation Awareness

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

Quantifying and Predicting Operationally-Relevant Performance in a Long-Duration Spaceflight Analog

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	Risk of Performance Decrements and Adverse Health Outcomes Resulting from Sleep Loss, Circadian Desynchronization, and Work Overload
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?
	Sleep-101: Given each crew member will experience multiple spaceflight hazards simultaneously, we need to identify and characterize the potential additive, antagonistic, or synergistic impacts of multiple stressors (e.g., Space Radiation, Altered Gravity, Isolation, altered immune, altered sleep) on crew sleep-wake cycles and/or circadian shifting, health and/or CNS/cognitive functioning to identify any identified adverse individual or team crew health, and/or operationally-relevant performance outcomes.

NSCOR for Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight: Emotional Valence and Social Processes in ICC/ICE Environments

Common Item(s)
	Risk of Adverse Cognitive or Behavioral Conditions and Psychiatric Disorders
	BMed-102: Given exposures to spaceflight hazards (space radiation, isolation), how do we identify individual susceptibility, monitor molecular/biomarkers and acceptable thresholds, and validate behavioral health and CNS/neurological/neuropsychological performance measures and domains of relevance to exploration class missions?

Developing and Validating Specific Medical Event Management Training Protocols for Flight Crews on Deep Space, Long-Duration Space Exploration Missions (NSBRI-Yule)