HRR - Task - Improving CV Risk Prediction -- Biomarkers and Beyond, Implications for Astronaut Selection and Monitoring During Prolonged Spaceflight (CV BIOMARKERS / DE LEMOS / ACTIVE)

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Improving CV Risk Prediction -- Biomarkers and Beyond, Implications for Astronaut Selection and Monitoring During Prolonged Spaceflight (CV BIOMARKERS / DE LEMOS / ACTIVE) (Completed)

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry
Principal Investigator: de Lemos, James

Short Title: CV Biomarkers

Responsible HRP Element: Exploration Medical Capability

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Specific Aim 1: To establish a consortium of biomarker and aerospace medicine experts to provide

recommendations regarding biomarker screening in the astronaut population, and to conduct collaborative research focused on the specific risk prediction needs of the astronaut population.

Specific Aim 2: To develop a multi-modality risk prediction tool for 10 year global CVD events that combines imaging and novel blood-based biomarkers.

Specific Aim 3: To develop a risk prediction tool for short-term (3 year) global CVD events.

Exploratory Aim 4: To work with NASA researchers in the Human Research Program to explore the feasibility of transforming the Longitudinal Study of Astronaut Health (LSAH) into a prospective state-of-the art cohort study of the astronaut corps.

Resources (None Listed)

Deliverables (1)

Mappings

Risk of Adverse Health Outcomes and Decrements in Performance Due to Medical Conditions that occur in Mission, as well as Long Term Health Outcomes Due to Mission Exposures

Medical-401: We need to characterize the predicted resource or risk constraints associated with exploration missions in order to determine which capabilities (and associated resources) should be included in an exploration medical system.

Improving CV Risk Prediction -- Biomarkers and Beyond, Implications for Astronaut Selection and Monitoring During Prolonged Spaceflight (CV BIOMARKERS / DE LEMOS / ACTIVE)

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CV-103: Determine whether the combined effects of relevant deep-space radiation and weightlessness induce additive or synergistic effects on the cardiovascular system, and whether it is of concern for development of disease.

Improving CV Risk Prediction -- Biomarkers and Beyond, Implications for Astronaut Selection and Monitoring During Prolonged Spaceflight (CV BIOMARKERS / DE LEMOS / ACTIVE)

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Risk Approach Plans (2)

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Common Item(s)
	Risk of Adverse Health Outcomes and Decrements in Performance Due to Medical Conditions that occur in Mission, as well as Long Term Health Outcomes Due to Mission Exposures