Task Development of a Flow-Perfused and Immunocompetent 3-D Vascular Model for Radiation Risk Assessment of Cardiovascular Disease and Countermeasure Screening (Completed)
Last Published:  04/20/22 11:43:24 AM (Central)
Short Title: 3-D Vascular Model
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Aim 1: Establish a 3-D tri-culture vascular model which incorporates aortic endothelial cells, smooth muscle cells, and macrophages.

Aim 2
: Adapt the 3-D model from its organotypic configuration within a hydrogel to a spheroid format for use in rotating wall vessel bioreactors.


Aim 3: Validate the utility of the 3-D vascular model for radiation risk assessment studies.
Resources (None Listed)