Task Oxidative Stress and the Cancer Risk of Space Radiation
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Oxidative Stress and Cancer Risk
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Aim 1: To examine chronic oxidative stresses and inflammatory responses in organs of mice exposed to isovelocity 1 GeV/n O, Si, or Ca ions that are targeted to the whole body.


Aim 2:
To determine the beneficial effects of a pre-exposure to low LET protons that

may minimize the harmful effects of a subsequent exposure to HZE particles.


Aim 3:
To measure oxidative changes and cancer incidence in non-irradiated organs

(liver, lung) after exposure of the head to an acute mean absorbed dose of 40 cGy of 1 GeV/u Ca,and to compare the observed changes with those in a targeted organ (brain). b) To examine the protective effect of whole-body pre-exposure to a conditioning dose of 20 cGy of 1 GeV protons delivered at low dose-rate prior to head exposure to acute dose of 40 cGy of 1 GeV/u Ca ions.

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