Short Title:
Chromosome Aberrations
Responsible HRP Element:
Space Radiation
Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Objective 1: Isolate progeny (clones) of irradiated single cells and analyze for the presence of transmissible chromosome aberrations
Objective 2: Next generation sequencing approaches will be employed to characterize, at the DNA level, the nature of breakpoint junctions of the chromosome translocations and inversions identified in Objective 1.
Objective 3: Examine cytogenetic Effects of Abrogating CtIP activity.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Characterization of the structural changes to the DNA of normal human cells that accompany the formation of transmissible chromosome aberrations caused by heavy ion irradiation.
Internal Customers:
Space Radiation
External Customers:
None