Funding Status:
Active - Currently funded and in progress
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Procurement Mechanism(s):
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Aims:
Aim 1. Determine the microenvironmental changes in hepatic lipids by MALDI-IMS after HZE-irradiation
Aim 2. Determine transcriptional changes in the hepatic microenvironment of
HZE- and gamma-irradiated samples, compared to controls.
Aim 3. Determine comprehensive ultra high-resolution lipidomic alterations as well as high-resolution targeted proteomic microenvironment changes in hepatic tissue of HZE- and 137Cs gamma ray-irradiated animals as well as non-irradiated controls.
Aim 4. Correlate large ‘omic datasets to construct biological pathways that elucidate molecular mechanisms of HCC carcinogenesis induced by HZE irradiation.