Short Title:
Epigenetic Regulation
Responsible HRP Element:
Space Radiation
Funding Status:
Completed - Task completed and produced a deliverable
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Procurement Mechanism(s):
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Aims:
Aim 1: Determine the impact of low dose HZE ions on perturbations in intestinal whole genome methylation and histone acetylation status.
Aim 2: Determine if colon adult stem cells are more susceptible to epigenetic perturbations induced by low dose HZE radiation than non-stem cells in the same colon crypt.
Aim 3: Determine the potential for dietary countermeasures that alter colonic microbiota and butyrate concentrations to mitigate the impact of low dose HZE radiation onepigenetic regulation of apoptosis in colon adult stem cells and daughter cells.
Category:
Risk Characterization, Quantification
Subcategory:
Evidence or Risk Characterization
Description:
Evidence on the impact of Si, Ti, or Fe ions on the regulation of colonocyte apoptosis in mice exposed to doses representative of the total doses on long-duration missions to Mars or asteroids with emphasis on the role of epigenetic mechanisms
Internal Customers:
Space Radiation
External Customers:
None