HRR - Task - SPACECOT: Studying Physiological and Anatomical Cerebral Effects of CO2 and Tilt [SPACECOT/BERSHAD]

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SPACECOT: Studying Physiological and Anatomical Cerebral Effects of CO2 and Tilt [SPACECOT/BERSHAD] (Completed)

Last Published: 04/20/22 11:43:24 AM (Central)

Task Book: Entry Unavailable
Principal Investigator: Bershad, Eric

Short Title: SPACECOT

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

National Space Biomedical Research Institute (NSBRI)

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Directed

Aims:

Specific Aim 1 – Determine the qualitative and quantitative changes in CBF, ICV, ICP, cognitive function and ocular structure from 1% CO2 /-12 degree HDT condition compared to ambient air/-12 degree HDT and ambient air/upright conditions using non-invasive brain/ocular monitoring devices and MRI.

Specific Aim 2 – Determine the acute (2 hours) effects of 3% CO2 /-12 HDT on CBF, ICV and cognitive function and ocular structure compared to 1% CO2 /-12 HDT, ambient/-12 HDT or ambient air/upright conditions using non-invasive brain/ocular monitoring devices and MRI.

Specific Aim 3 – Evaluate the suitability of Envihab-DLR to successful implement multiple measures in 3 simultaneous subjects in bed-rest position, and perform NASA standard measures for ground-based analogs of spaceflight.

Resources (Ground Analog)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
This task will inform the VIIP 12 knowledge gap by measuring the effect of CO2 exposure on ocular structure and cerebral blood flow during head-down tilt bedrest so that the efficacy of a head-down tilt/CO2 VIIP analog can be evaluated.

Internal Customers:
None External Customers:
None

Mappings

Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS-103: Determine whether ground-based induced fluid shifts lead to ocular manifestations.

SPACECOT: Studying Physiological and Anatomical Cerebral Effects of CO2 and Tilt [SPACECOT/BERSHAD]

Related Tasks (101)

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Risk Approach Plans (2)

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Ground-Based Flight Analogs Bedrest [e.g., envihab, other bedrest facilities]
Number of Subjects	6

Common Item(s)
	Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)