Last Published:  04/20/22 11:43:24 AM (Central)
Short Title: Cancer Biomarkers
Responsible HRP Element: Space Radiation
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):

Project 1 - identify biomarkers for susceptibility to HZE ion carcinogenesis and for early disease detection using genetic and systems biology approaches. Uses integrative “omics” approaches over multiple levels of biological organization and involves multiple species.

Project 2 - focuses on the mechanisms underlying the increased malignancy of HZE ion-induced tumors compared with their spontaneous or γ- ray-induced counterparts.

Project 3 - examines the critical question of risk from protracted exposures to high LET radiation at low doses and dose rates. Uses chronic exposures to high LET associated neutron radiation as a surrogate for conditions of space-relevant fluence rates and total doses to estimate the carcinogenic effects.

Project 4 - utilizes the resources (irradiated mice and “omics” results) generated in the first three projects to study the neurobehavioral consequences of HZE ion and neutron exposures and whether they are related to cancer outcome measures and predicted by the same or distinct biomarkers
Resources (None Listed)