Task The Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight
Last Published:  07/30/21 01:05:34 PM (Central)
Short Title: Food Physiology
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
Human Health Countermeasures (HHC) Element
Other: J Craig Ventner Institute
Space Biology Program
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Solicited
Aims:

Spaceflight has demonstrated concerning impacts to human physiology, including well documented immune system dysregulation. Diet, immune function, and the microbiome are interlinked, but diet is the only one of these factors that we have the ability to easily, and significantly, alter on Earth or during flight. It is expected that as we understand dietary impacts more thoroughly, we may continue to improve the spaceflight diet in direct support of crew health. We propose here an interdisciplinary study that will determine the effect of the current spaceflight diet compared to an "enhanced" spaceflight diet (25% more foods rich in omega-3 fatty acids, lycopene, flavonoids, fruits, and vegetables), with complete dietary tracking, on immune function, gut microbiota composition, and nutritional status of crew in ground-control analogs, and on International Space Station (ISS) missions. We hypothesize that by increasing consumption of fruits and vegetables and bioactive compounds (e.g., omega-3 fatty acids, lycopene, flavonoids) and enhancing overall nutritional intake during spaceflight (or a ground-based analog of spaceflight) we will improve human immunological profiles, the taxonomic profile of the gut microbiota, and nutritional status biomarkers. Positive associations between beneficial improvements will provide evidence to better predict the impact of diet on crew health and adaptation to spaceflight and to design targeted more-efficient dietary interventions. Specifically, we aim to:

  1. Implement a pilot ground-control study with analog crew randomized between two spaceflight diets, and determine diet effects on immune dysregulation, including leukocyte distribution, inflammatory cytokine profiles, T cell function, and other relevant immunological markers, the taxonomic and metatranscriptomic profile of the gut microbiome, and nutritional biomarkers and metabolites at selected intervals, and statistically evaluate to associate shifts across each measure and in relation to nutrient intake; and
  2. Determine effects of diet on immune dysregulation, including leukocyte distribution, inflammatory cytokine profiles, T cell function, and other relevant immunological markers, the taxonomic and metatranscriptomic profile of the gut microbiome, and nutritional biomarkers and metabolites at selected intervals in spaceflight and statistically evaluate to associate shifts across each measure, and in relation to ground-control data.

This study specifically addresses FOOD-3 “We need to identify the methods, technologies, and requirements that will deliver a food system that provides adequate safety, nutrition, and acceptability for proposed long-duration Design Reference Mission operations,” by defining targeted more-efficient dietary interventions in relation to crew health, and the associated food system requirements. It also addresses Space Biology - B.4 Research Emphasis 3 - Understanding How Complex Organisms Adapt to Spaceflight, by providing detailed comprehensive analysis of the effect of diet on the human immune system, gut microbiota, and nutritional status during human adaptation to spaceflight.

Mappings
RiskRisk of Adverse Health Effects Due to Host-Microorganism Interactions
You are here!TaskThe Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight

RiskRisk of Adverse Health Event Due to Altered Immune Response
You are here!TaskThe Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight

RiskRisk of Performance Decrement and Crew Illness Due to Inadequate Food and Nutrition
You are here!TaskThe Integrated Impact of Diet on Human Immune Response, the Gut Microbiota, and Nutritional Status During Adaptation to Spaceflight