Task STOP VIIP Study: Safe and Effective Countermeasures to Reduce Intracranial Pressure and Ameliorate VIIP in Astronauts [STOP VIIP/Levine] (Completed)
Last Published:  03/26/21 03:34:00 PM (Central)
Short Title: STOP VIIP
Responsible HRP Element: Human Health Countermeasures
Collaborating Org(s):
National Space Biomedical Research Institute (NSBRI)
Funding Status: Completed - Task completed and produced a deliverable
Procurement Mechanism(s):
Directed
Aims:
Specific Aim 1: Using direct invasive recording of ICP, we will determine the optimal level of LBNP required to cause a sustained reduction in ICP towards that observed in the upright position, while avoiding hypotension and maintaining cerebral perfusion.

Specific Aim 2: We will examine the long-term efficacy of nightly LBNP (6-8 hours) to simulate the upright position and ICP circadian variability and prevent structural changes in the eye during multiple (4) days of HDT bedrest. We will use comprehensive, non-invasive state-of-the-art imaging to examine the structure of the visual apparatus, the intra- and extra-cranial veins, cerebral spinal fluid production and localized intracranial fluid shifts using high-resolution physiological, optical and magnetic resonance techniques, combined with invasive direct measurement of ICP.
Resources (None Listed)
Mappings
RiskRisk of Spaceflight Associated Neuro-ocular Syndrome (SANS)
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