HRR - Task - Vestibular-Evoked Myogenic Potentials in Microgravity

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Vestibular-Evoked Myogenic Potentials in Microgravity

Last Published: 07/30/20 02:45:15 PM (Central)

Task Book: Entry Unavailable
Principal Investigator: Campbell, David

Short Title: VEMP

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Human Health Countermeasures (HHC) Element

Other:

Funding Status: Terminated - A formerly active task that was stopped before its completion date due to deselection, descoping, reorganization etc.

Procurement Mechanism(s):

Directed

Aims:
Compare cVEMP (Cervical VEMP) and oVEMP (Ocular VEMP) tests using both auditory and mechanical stimuli to assess utricular and saccular functions in normative ground subjects.

Resources (Other)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:
The results from this study will contribute to gap closure by providing an improved VEMP method to assess utricular and saccular function for use in future studies designed to provide a better understanding of the long-term adaptation of the otolith system to the conditions of spaceflight.

The flight portion of the study was deselected by the European Space Agency, thus only the ground-based study investigating novel methods (head tapper and mini-shaker to provide bone conducted stimuli) to elicit vestibular-evoked myogenic potential (VEMP) responses was conducted. The results showed that both the head tapper and mini-shaker can elicit VEMP responses but additional development would be required to validate either method to effectively measure changes in otolith gain during spaceflight, especially at threshold levels.

Internal Customers:
Human Health Countermeasures
External Customers:
None

Mappings

Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight

SM-101: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after g transitions. Critical mission tasks: Ability to stand upright without falling, ability to walk safely without tripping or stumbling, ability to quickly egress from a vehicle, etc.

SM-102: Effects of short and long-duration weightlessness, with and without deep-space radiation, on manual control (fine motor control) after g transitions. Critical mission tasks: Hand-eye coordination, robotic tasks, driving (e.g., rovers), docking, landing, manipulating controls/switches/touch-screens, etc.

SM-103: Effects of short and long-duration weightlessness, with and without deep-space radiation, on spatial orientation and motion sickness after G transitions. Performance impacts that effect critical mission tasks: G-transition motion sickness, diplopia, hand-eye coordination, autonomic dysfunction, vertigo.

SM-104: How do weightlessness-induced changes in sensorimotor/vestibular function relate to and/or interact with changes in other brain functions (sleep, cognition, attention).

Vestibular-Evoked Myogenic Potentials in Microgravity

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PRRs (2)

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Common Item(s)
	Risk of Impaired Control of Spacecraft/Associated Systems and Decreased Mobility Due to Vestibular/Sensorimotor Alterations Associated with Spaceflight
	SM-101: Characterize the effects of short and long-duration weightlessness, with and without deep-space radiation, on postural control and locomotion (gross motor control) after g transitions. Critical mission tasks: Ability to stand upright without falling, ability to walk safely without tripping or stumbling, ability to quickly egress from a vehicle, etc.
	SM-103: Effects of short and long-duration weightlessness, with and without deep-space radiation, on spatial orientation and motion sickness after G transitions. Performance impacts that effect critical mission tasks: G-transition motion sickness, diplopia, hand-eye coordination, autonomic dysfunction, vertigo.