Task Bed Rest Combined with 0.5% CO2 as a Spaceflight Analog to Study Neurocognitive Changes: Extent, Longevity, and Neural Bases
Last Published:  07/29/22 01:33:24 PM (Central)
Short Title: Neuromapping CO2 Bedrest
Responsible HRP Element: Human Factors and Behavioral Performance
Collaborating Org(s):
Funding Status: Active - Currently funded and in progress
Procurement Mechanism(s):
Aim 1: Identify changes in brain structure, function, and network integrity as a function of 30 days head down tilt bed rest plus 0.5% CO2 and characterize their time course.
Aim 2: Specify relationships between structural and functional brain changes and performance and characterize their time course.
Aim 3: Identify predictors of individual differences in bed rest plus 0.5% CO2 responses.
The following supplemental aims were added:

1S. Characterize the dose-response effect of elevated CO2 on gadolinium contrast clearance in the human brain glymphatic system over a period of approximately 24 hours. 

2S. Assess changes in brain-derived stress biomarkers in the blood that correlate with neurological changes in response to elevated CO2.

3S. Evaluate neurobehavioral responses in response to elevated CO2.