HRR - Task - The impact of an ISS mission on the anti-viral and functional properties of NK-cells, T-cells, B-cells and dendritic cells (Simpson) Functional immune

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The impact of an ISS mission on the anti-viral and functional properties of NK-cells, T-cells, B-cells and dendritic cells (Simpson) Functional immune

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry
Principal Investigator: Simpson, Richard

Short Title: Anti-viral and functional properties of immune cells

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Active - Currently funded and in progress

Procurement Mechanism(s):

Solicited

Aims:

[A] Determine the in-flight status of immune dysregulation (innate + adaptive) in conjunction with relevant parameters from other disciplines (nutrition, radiation, virology, host-pathogen, stress, etc.).

[B] Determine the post-flight time course to full recover for dysregulated parameters.

[C] Derive a final refined monitoring strategy encompassing innate immunity, adaptive immunity and relevant parameters from other disciplines which will be appropriate to validate countermeasures.

Integration/Unique Aspects: functional immune is a hybrid study that incorporates a directed portion with solicited portions.

Resources (Flight)

Deliverables (1)

Category:
Subcategory:

Description:

The functional immune study is a large integrated multi-laboratory internal/external study during the lifespan of ISS. including work data from the Integrated Immune, and the Salivary Markers studies. This study should essentially close Gap IM-01 (post completion status ~95%). The deliverable will be a report that will feed into the HHC Integrated Countermeasure Suite. The Integrated immune study confirmed certain aspects of adaptive immunity but left many others relatively investigated.

Internal Customers:
Human Health Countermeasures
External Customers:
None

Mappings

Risk of Adverse Health Event Due to Altered Immune Response

IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.

IM-105: Identify immune biomarkers that correlate with known spaceflight-related immune dysfunction and immune outcomes, as a first step in designing in-flight monitoring paradigms.

The impact of an ISS mission on the anti-viral and functional properties of NK-cells, T-cells, B-cells and dendritic cells (Simpson) Functional immune

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PRRs (1)

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Common Item(s)
	Risk of Adverse Health Event Due to Altered Immune Response
	IM-101: Evaluate the effects of deep-space radiation on immune dysfunction, as an additional hazard to the effects of psychophysiological stress and weightlessness.