Description:
1) Determine the effects of simulated spaceflight on endothelial phenotype via changes in
circulating endothelial microparticles
2) Determine the effects of simulate spaceflight on circulating microRNA levels
3) Determine the role of cardiac-specific microRNA on changes in ventricular volume and
performance.
4) Evaluate the relationship between cardiovascular tissue-specific microRNAs on the
decrease in aerobic exercise capacity following simulated spaceflight
5) Determine the effects of simulated spaceflight on serum concentrations of Sclerostin
6) Determine the role changes in Sclerostin has on standard measurements of bone
mineral density
7) Determine the role of bone-specific microRNA on standard measurements of bone
mineral density
8) Provide a group of potential biomarkers that can be used as an in-flight capability to
monitor cardiovascular and bone physiology.