HRR - Task - Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

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Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures (Completed)

Last Published: 07/30/21 01:05:34 PM (Central)

Task Book: Entry
Principal Investigator: Ade, Carl

Short Title: omics markers of cardio and bone

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Determine if tissue-specific cardiovascular-health related circulating

endothelial microparticles and microRNA (c-miRNA) are altered following 30 days HDBR and

how they relate to changes in maximal aerobic capacity, orthostatic tolerance, and

intraocular pressure.

Determine if bone-health specific circulating biomarkers and c-miRNA are

altered following 30 days HDBR and if they are related to changes in bone turnover and bone

mass changes.

Resources (Ground Analog)

Deliverables (1)

Category:
Subcategory:

Description:

1) Determine the effects of simulated spaceflight on endothelial phenotype via changes in

circulating endothelial microparticles

2) Determine the effects of simulate spaceflight on circulating microRNA levels

3) Determine the role of cardiac-specific microRNA on changes in ventricular volume and

performance.

4) Evaluate the relationship between cardiovascular tissue-specific microRNAs on the

decrease in aerobic exercise capacity following simulated spaceflight

5) Determine the effects of simulated spaceflight on serum concentrations of Sclerostin

6) Determine the role changes in Sclerostin has on standard measurements of bone

mineral density

7) Determine the role of bone-specific microRNA on standard measurements of bone

mineral density

8) Provide a group of potential biomarkers that can be used as an in-flight capability to

monitor cardiovascular and bone physiology.

Internal Customers:
Human Health Countermeasures
External Customers:
None

Mappings

Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

Risk of Cardiovascular Adaptations Contributing to Adverse Mission Performance and Health Outcomes

CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

Risk Of Early Onset Osteoporosis Due To Spaceflight

Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

Risk of Impaired Performance Due to Reduced Muscle Size, Strength and Endurance

M6: Develop pre-flight, in-flight, and post-flight evaluations to determine if muscle function standards are met.

Omics and biochemical markers of cardiovascular and bone health: Relationship with bedrest and standard physiological measures

Related Tasks (245)

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Risk Approach Plans (3)

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Ground-Based Flight Analogs Bedrest [e.g., envihab, other bedrest facilities]
Number of Subjects	24

Common Item(s)
	Risk of Bone Fracture due to Spaceflight-induced Changes to Bone
	Risk Of Early Onset Osteoporosis Due To Spaceflight
	Osteo 5: We need an inflight capability to monitor bone turnover and bone mass changes during spaceflight.