HRR - Task - Gravitational dose and multi-system physiologic response

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Gravitational dose and multi-system physiologic response (Completed)

Last Published: 11/23/20 11:55:12 AM (Central)

Task Book: Entry
Principal Investigator: Ploutz-Snyder, Lori

Short Title: AG dose

Responsible HRP Element: Human Health Countermeasures

Collaborating Org(s):

Funding Status: Completed - Task completed and produced a deliverable

Procurement Mechanism(s):

Solicited

Aims:

Characterize the relationship between gravitational dose and acute physiologic responses of the cardiovascular, cerebrovascular, ocular, muscular, and sensorimotor systems.

Resources (Ground Analog)

Deliverables (1)

Category: Risk Characterization, Quantification
Subcategory: Evidence or Risk Characterization

Description:

G-thresholds and dose-response of CV, VIIP, MS, And SM.

Developing the dose-response curve for gravitational load is expected to be useful to inform the

next step in countermeasure development.

Data from this study will provide evidence to determine if partial gravity would be sufficient for exploration missions.

Internal Customers:
None External Customers:
None

Mappings

Risk of Impaired Performance Due to Reduced Muscle Mass, Strength & Endurance

M14: Indentify adjuncts to exercise countermeasures that can be used to better mitigate muscle loss.

Gravitational dose and multi-system physiologic response

Risk of Spaceflight Associated Neuro-ocular Syndrome (SANS)

SANS-303: Test the efficacy of AG (centrifugation)-induced fluid shift versus other mechanical countermeasures.

Gravitational dose and multi-system physiologic response

Risk of Spaceflight Induced Cardiovascular Disease

CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.

Gravitational dose and multi-system physiologic response

Related Tasks (251)

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PRRs (4)

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Ground-Based Flight Analogs Reduced Gravity Flight
Number of Subjects	15

Common Item(s)
	Risk of Spaceflight Induced Cardiovascular Disease
	CVD-101: Determine whether long-duration weightlessness induces cardiovascular structural and functional changes and/or oxidative stress & damage (OSaD)/inflammation, that can contribute to development of disease.